| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.C.24.1.1 | Class IIa bacteriocin Pediocin PA-1 precursor of 62 aas. Class II bacteriocins are unmodified membrane-active peptides that act over a narrow spectrum of target bacteria. They bind a specific receptor protein on the membrane to form a pore, leading to membrane permeabilization and cell death. The specific receptor acts as a docking molecule, not as a structural piece of the pore, if the bacteriocin is anchored to the membrane (Ríos Colombo et al. 2019). Pediocin-like (or class IIa) bacteriocins (PLBs) exhibit antibacterial activity against several Gram-positive bacterial strains by forming pores in the cytoplasmic membrane of target cells with a specific receptor, the mannose phosphotransferase system (man-PTS) (Zhu et al. 2022). The N-terminal β-sheet region of pediocin PA-1 attaches to the extracellular surface of the man-PTS core domain, whereas the C-terminal half penetrates the membrane and cracks the man-PTS like a wedge. | Bacteria |
Bacillota | Pediocin PA-1 precursor of Pediococcus acidilactici |
|
1.C.24.1.2 | Class IIa bacteriocin Sakacin P precursor | Bacteria |
Bacillota | Sakacin P of Lactobacillus sake |
|
1.C.24.1.3 | Class IIa bacteriocin Pisciolin 126 precursor | Bacteria |
Bacillota | Pisciolin 126 precursor of Carnobacterium piscicola |
|
1.C.24.1.4 | Class IIa bacteriocin Enterocin A | Bacteria |
Bacillota | Enterocin A of Enterococcus faecium |
|
1.C.24.1.5 | Class IIa bacteriocin Mesentericin Y105 precursor | Bacteria |
Bacillota | Mesentericin Y105 precursor of Leuconostoc mesenteroides |
|
1.C.24.1.6 | Class IIa bacteriocin Leucocin A precursor | Bacteria |
Bacillota | Leucocin A precursor of Leuconostoc gelidum |
|
1.C.24.1.7 | Class IIa bacteriocin Carno(bacterio)cin B2 precursor | Bacteria |
Bacillota | Carnocin B2 of Carnobacterium piscicola |
|
1.C.24.1.8 | Class IIa bacteriocin Sakacin A precursor (Identical to Curvacin A of Lactobacillus curvatus; P0A311) (Haugen et al. 2008). | Bacteria |
Bacillota | Sakacin A precursor of Lactobacillus sakei ( P0A310) |
|
1.C.24.1.9 | Class IIa bacteriocin Bavaricin MN precursor | Bacteria |
Bacillota | Bavaricin MN of Lactobacillus sakei |
|
1.C.24.1.10 | Class IIc sec-secreted bacteriocin Enterocin P precursor, EntP | Bacteria |
Bacillota | EntP of Enterococcus faecium |
|
1.C.24.1.11 | Class IIa bacteriocin, Ubericin A of 70 aas (Heng et al., 2007). It is a heat-stable antibiotic with bacteriolytic activity against Listeria spp., E. hirae, E. faecalis ATCC 19433, S. bovis 83, S. uberis 42 and L. lactis. | Bacteria |
Bacillota | Ubericin A of Streptococcus uberis (A9Q0M7) |
|
1.C.24.1.12 | Bacteriocin 41 precursor, BacA (pore-forming ability not demonstrated; Tomita et al., 2008) | Bacteria |
Bacillota | BacA of Enterococcus faecalis
(B1NRV2) |
|
1.C.24.1.13 | Divergicin M35 (43aas) (Naghmouchi et al., 2008) (The C-terminal residues most resemble BacA (TC#1.C.24.1.12)). | Bacteria |
Bacillota | Divergicin M35 of Carnobacterium divergens (P84962) |
|
1.C.24.1.14 | Listeria-active class IIa peptide, Lactococcin MMFII (may form pores in lipid bilayers, but also in combination with proteins of the mannose phosphotransferase system (PTS)) (Ferchichi et al., 2001). | Bacteria |
Bacillota | Loctococcin MMFII of Lactococcus lactis (P83002) |
|
1.C.24.1.15 | Enterocin CRL35 of 58 aas, MunA. Class II bacteriocins are unmodified membrane-active peptides that act over a narrow spectrum of target bacteria. They bind a specific receptor protein on the membrane to form a pore, leading to membrane permeabilization and cell death. The specific receptor acts as a docking molecule, not as a structural part of the pore, but the bacteriocin must be anchored to the membrane (Ríos Colombo et al. 2019). The ABC efflux porter is MunB (TC# 3.A.1.112.11). The enterocin CR35 immunity protein is MunC (98 aas; possibly 2 TMSs; Q6TGQ5). | Bacteria |
Bacillota | Enterocin ARL35 of Enterococcus mundtii |
|
1.C.24.1.16 | Uncharacterized protein of 70 aas and 2 TMSs. | Bacteria |
Chlamydiota | UP of Chlamydia trachomatis |
|
1.C.24.1.17 | Carnobaceriocin B (BM1) of 61 aas and 2 TMSs. | None |
Fungi, Ascomycota | Carnobacteriocin of Neurospora crassa |
|
1.C.24.2.1 | Ubercin K of 75 aas. | None |
Bacillati, Bacillota | Ubercin K of Streptococcus uberis |
|
1.C.24.2.2 | Bacteriocin of 88 aas and possibly 1 or 2 TMSs, N- and C-terminal. | None |
Bacillati, Bacillota | Bacteriocin of Streptococcus equi subsp. equi 4047 |
|
1.C.24.2.3 | Bacteriocin of 65 aas, possibly with 2 TMSs.. | None |
Bacillati, Bacillota | Bacteriocin of Lactobacillus crispatus |
|
1.C.24.2.4 | Bacteriocin of 84 aas and possibly 2 TMSs, the more hydrophobic one being at the C-terminus. | None |
Bacillati, Bacillota | Bacteriocin of Streptococcus halichoeri |
|
1.C.24.2.5 | Bacteriocin of 53 aas | None |
Bacillati, Bacillota | Bacteriocin of Streptococcus ruminantium |