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|---|---|
| Accession Number: | P07357 |
| Protein Name: | Complement component C8 alpha chain |
| Length: | 584 |
| Molecular Weight: | 65163.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Secreted1 / Multi-pass membrane protein2 |
| Substrate | molecule |
Cross database links:
| DIP: | DIP-1125N |
|---|---|
| RefSeq: | NP_000553.1 |
| Entrez Gene ID: | 731 |
| Pfam: | PF00057 PF01823 PF00090 |
| OMIM: |
120950 gene+phenotype |
| KEGG: | hsa:731 |
Gene Ontology
GO:0005615
C:extracellular space
GO:0005579
C:membrane attack complex
GO:0006957
P:complement activation, alternative pathway
GO:0006958
P:complement activation, classical pathway
GO:0019835
P:cytolysis
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References (12)[1] “Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA.” Rao A.G.et.al. 2820471 [2] “Genomic organization of human complement protein C8 alpha and further examination of its linkage to C8 beta.” Michelotti G.A.et.al. 7759071 [3] “The DNA sequence and biological annotation of human chromosome 1.” Gregory S.G.et.al. 16710414 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure.” Steckel E.W.et.al. 7440581 [6] “The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.” Hofsteenge J.et.al. 10551839 [7] “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.” Liu T.et.al. 16335952 [8] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.” Chen R.et.al. 19159218 [9] “Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense.” Hadders M.A.et.al. 17872444 [10] “Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.” Slade D.J.et.al. 18440555 [11] “Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding.” Lovelace L.L.et.al. 17692377 [12] “The eighth component of human complement: molecular basis of C8A (C81) polymorphism.” Zhang L.et.al. 7649542
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| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MFAVVFFILS LMTCQPGVTA QEKVNQRVRR AATPAAVTCQ LSNWSEWTDC FPCQDKKYRH 61: RSLLQPNKFG GTICSGDIWD QASCSSSTTC VRQAQCGQDF QCKETGRCLK RHLVCNGDQD 121: CLDGSDEDDC EDVRAIDEDC SQYEPIPGSQ KAALGYNILT QEDAQSVYDA SYYGGQCETV 181: YNGEWRELRY DSTCERLYYG DDEKYFRKPY NFLKYHFEAL ADTGISSEFY DNANDLLSKV 241: KKDKSDSFGV TIGIGPAGSP LLVGVGVSHS QDTSFLNELN KYNEKKFIFT RIFTKVQTAH 301: FKMRKDDIML DEGMLQSLME LPDQYNYGMY AKFINDYGTH YITSGSMGGI YEYILVIDKA 361: KMESLGITSR DITTCFGGSL GIQYEDKINV GGGLSGDHCK KFGGGKTERA RKAMAVEDII 421: SRVRGGSSGW SGGLAQNRST ITYRSWGRSL KYNPVVIDFE MQPIHEVLRH TSLGPLEAKR 481: QNLRRALDQY LMEFNACRCG PCFNNGVPIL EGTSCRCQCR LGSLGAACEQ TQTEGAKADG 541: SWSCWSSWSV CRAGIQERRR ECDNPAPQNG GASCPGRKVQ TQAC