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1.C.39.3.5 Complement protein C9; targets bacteria (McCormack et al. 2013). β-Hairpins in C8α and C9 play a direct role in MAC membrane penetration and pore formation (Weiland et al. 2014).
Accession Number:	P48770
Protein Name:	CO9 aka C9
Length:	547
Molecular Weight:	62014.00
Species:	Equus caballus (Horse) [9796]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Secreted¹ / Multi-pass membrane protein²
Substrate	molecule

RefSeq:	NP_001075419.1
Entrez Gene ID:	100034183
Pfam:	PF00057 PF01823
KEGG:	ecb:100034183
Gene Ontology GO:0005576 C:extracellular region GO:0005579 C:membrane attack complex GO:0006957 P:complement activation, alternative pathway GO:0006958 P:complement activation, classical pathway GO:0019835 P:cytolysis
References (1) [1] “Chimeric horse/human recombinant C9 proteins identify the amino acid sequence in horse C9 responsible for restriction of hemolysis.” Tomlinson S.et.al. 7541424

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSAGRTFAFA ICILEVSVLT AGPTPNYAPE PEQQSGTPLP IDCRMSSWSE WSECDPCLRQ 
61:	MFRSRSIEVF GQFNGQRCVD AVGDRRQCVP TEACEEVEDD CGNDFQCGTG RCIKKRLLCN 
121:	GDNDCGDFSD EDDCENDPRP PCRERVVEES ELARTAGYGI NILGMDPLST PFDNEYYNGL 
181:	CDRVRDGNTL TYYRKPWNLA SLAYETKADK NFRIEHYEQQ IQAFRSVIEE RRSHFNADFT 
241:	LKFTPTEAKK CKQEPEESCN GTDSSENRIF RFAYSKNETY QLFLSYSSKK EKMFLHVKGV 
301:	IQLGKFVMRS RDVVLTTTFL DDIKALPTAY EKGEYIAFLE TYGTHYSSSG SLGGLYELIY 
361:	VLDKASMDQK GVELRDIQRC LGFNLDLSLK DKYEVTAKID KNDCLKRNEK EIVNIMDGSL 
421:	IDDVISLIRG GTRKYAFELK EKLLKGAKTV NVTDFVNWAS SLNDAPVLIS QRLSPIYNLI 
481:	PVKMKDAHQK KQNLERAIED YINEFSVRKC HPCQNGGTVI QIDGQCLCSC PIAFEGIACE 
541:	TGKKKIS

1.C.39.3.5
Complement protein C9; targets bacteria (McCormack et al. 2013). β-Hairpins in C8α and C9 play a direct role in MAC membrane penetration and pore formation (Weiland et al. 2014).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

1.C.39.3.5Complement protein C9; targets bacteria (McCormack et al. 2013). β-Hairpins in C8α and C9 play a direct role in MAC membrane penetration and pore formation (Weiland et al. 2014).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

1.C.39.3.5
Complement protein C9; targets bacteria (McCormack et al. 2013). β-Hairpins in C8α and C9 play a direct role in MAC membrane penetration and pore formation (Weiland et al. 2014).