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1.C.61 The Streptococcus pyogenes Streptolysin S (Streptolysin S) Family

Streptolysin S of Streptococcus pyogenes is a small protein of 53 aas encoded by the pel/sagA gene. It probably contains a 17 aa leader sequence that is processed to a 36 aa polypeptide that is the key constituent of Streptolysin S. Antibodies against a C-terminal region of SagA prevents pore formation and hemolysis of sheep erythrocytes. This oxygen stable hemolysin mediates β-hemolysis. The protein exhibits a single TMS (residues 19-36 in the unprocessed 53 aa protein). It has no homologues in the current databases.

The transport reaction catalyzed by Streptolysin S is:

small molecules (in) small molecules (out).

References associated with 1.C.61 family:

Carr, A., D.D. Sledjeski, A. Podbielski, M.D.P. Boyle, and B. Kreikemeyer. (2001). Similarities between complement-mediated and streptolysin S-mediated hemolysis. J. Biol. Chem. 276: 41790-41796. 11546819
Molloy, E.M., P.D. Cotter, C. Hill, D.A. Mitchell, and R.P. Ross. (2011). Streptolysin S-like virulence factors: the continuing sagA. Nat. Rev. Microbiol. 9: 670-681. 21822292