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1.E.40 The Mycobacterial 4 TMS Phage Holin (MP4 Holin) Family

A member of the Mycobacterial 4 TMS Phage Holin family was first identified by Catalao et. al (Catalão et al. 2012). This family includes several 4 TMS homologues, all of which are from phage, bacteria and archaea. None of these proteins is functionally characterized.  These proteins have their 4 TMSs present in an apparent 2 + 2 TMS arrangement, and the two pairs of 2 TMSs may be duplicates of each other.

This family belongs to the: Holin IV Superfamily .

References associated with 1.E.40 family:

Catalao MJ., Gil F., Moniz-Pereira J., Sao-Jose C. and Pimentel M. (2013). Diversity in bacterial lysis systems: bacteriophages show the way. FEMS Microbiol Rev. 37(4):554-71. 23043507
Meng, L.H., F. Ke, Q.Y. Zhang, and Z. Zhao. (2022). Functional Analysis of the Endopeptidase and Holin From Cyanophage PaV-LD. Front Microbiol 13: 849492. 35572663
Palmer, M., B.P. Hedlund, S. Roux, P.K. Tsourkas, R.K. Doss, C. Stamereilers, A. Mehta, J.A. Dodsworth, M. Lodes, S. Monsma, T. Glavina Del Rio, T.W. Schoenfeld, E.A. Eloe-Fadrosh, and D.A. Mead. (2020). Diversity and Distribution of a Novel Genus of Hyperthermophilic Viruses Encoding a Proof-Reading Family-A DNA Polymerase. Front Microbiol 11: 583361. 33281778