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Accession Number: | Q96NT5 |
Protein Name: | Proton-coupled folate transporter aka HCP4 |
Length: | 459 |
Molecular Weight: | 49771.00 |
Species: | Homo sapiens (human) [9606] |
Number of TMSs: | 12 |
Location1 / Topology2 / Orientation3: | Apical cell membrane1 / Multi-pass membrane protein2 |
Substrate |
Cross database links:
RefSeq: | NP_542400.2 |
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Entrez Gene ID: | 113235 |
Pfam: | PF07690 |
OMIM: |
229050 phenotype 611672 gene |
KEGG: | hsa:113235 hsa:113235 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0005737
C:cytoplasm
GO:0016021
C:integral to membrane
GO:0005542
F:folic acid binding
GO:0008517
F:folic acid transporter activity
GO:0015884
P:folic acid transport
GO:0015232
F:heme transporter activity
GO:0006879
P:cellular iron ion homeostasis
GO:0046655
P:folic acid metabolic process
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References (31)[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [3] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [4] “Identification of an intestinal heme transporter.” Shayeghi M.et.al. 16143108 [5] “Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.” Qiu A.et.al. 17129779 [6] “Haem carrier protein 1 (HCP1): expression and functional studies in cultured cells.” Latunde-Dada G.O.et.al. 17156779 [7] “The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption.” Zhao R.et.al. 17446347 [8] “Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium.” Sharma S.et.al. 17335806 [9] “Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.” Nakai Y.et.al. 17475902 [10] “Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.” Wang B.et.al. 19007248 [11] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.” Daub H.et.al. 18691976 [12] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [13] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.” Chen R.et.al. 19159218 [14] “A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function.” Lasry I.et.al. 18559978 [15] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [16] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [17] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [18] “Identification of an intestinal heme transporter.” Shayeghi M.et.al. 16143108 [19] “Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.” Qiu A.et.al. 17129779 [20] “Haem carrier protein 1 (HCP1): expression and functional studies in cultured cells.” Latunde-Dada G.O.et.al. 17156779 [21] “The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption.” Zhao R.et.al. 17446347 [22] “Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium.” Sharma S.et.al. 17335806 [23] “Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.” Nakai Y.et.al. 17475902 [24] “Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.” Wang B.et.al. 19007248 [25] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.” Daub H.et.al. 18691976 [26] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [27] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.” Chen R.et.al. 19159218 [28] “A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function.” Lasry I.et.al. 18559978 [29] “Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption.” Mahadeo K.et.al. 20686069 [30] “Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.” Shin D.S.et.al. 20805364 [31] “Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption.” Shin D.S.et.al. 21333572
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External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MEGSASPPEK PRARPAAAVL CRGPVEPLVF LANFALVLQG PLTTQYLWHR FSADLGYNGT 61: RQRGGCSNRS ADPTMQEVET LTSHWTLYMN VGGFLVGLFS STLLGAWSDS VGRRPLLVLA 121: SLGLLLQALV SVFVVQLQLH VGYFVLGRIL CALLGDFGGL LAASFASVAD VSSSRSRTFR 181: MALLEASIGV AGMLASLLGG HWLRAQGYAN PFWLALALLI AMTLYAAFCF GETLKEPKST 241: RLFTFRHHRS IVQLYVAPAP EKSRKHLALY SLAIFVVITV HFGAQDILTL YELSTPLCWD 301: SKLIGYGSAA QHLPYLTSLL ALKLLQYCLA DAWVAEIGLA FNILGMVVFA FATITPLMFT 361: GYGLLFLSLV ITPVIRAKLS KLVRETEQGA LFSAVACVNS LAMLTASGIF NSLYPATLNF 421: MKGFPFLLGA GLLLIPAVLI GMLEKADPHL EFQQFPQSP