2.A.100.1.7
Ferroportin1 (Fpn1) of 562 aas and 12 TMSs (Rafiee et al. 2012). Missense mutations in Fpn1, an intestinal and macrophage iron exporter, have been identified between TMSs 3 and 4 in the zebrafish anemia mutant weissherbst (weh(Tp85c-/-)) and in patients with type 4 hemochromatosis. Thus, ferroportin1 is required for normal iron cycling in both humans and zebrafish (Fraenkel et al. 2005).
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| Accession Number: | Q9I9R3 |
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| Protein Name: | Solute carrier family 40 member 1 |
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| Length: | 562 |
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| Molecular Weight: | 61761.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MDSPASKKPR CERFREFFKS AKFLIYVGHA LSTWGDRMWN FAVAVFLVEL YGNSLLLTAV
61: YGLVVAGSVL LLGAIIGDWV DKNPRLKVAQ TSLVVQNSAV ILCGALLMAV FQFKQQLSSM
121: YDGWLLTTCY IMVISIANIA NLASTAMSIT IQRDWVVVVA GDDRSKLADM NATVRIIDQL
181: TNILAPMLVG QIMAFGSHFI GCGFISGWNL FSMCLEYFLL WKVYQKTPAL AFKAGQKDSD
241: DQELKHLNIQ KEIGNTESPV EASQLMTESS EPKKDTGCCY QMAEPIRTFK DGWVAYYNQS
301: IFFAGMSLAF LYMTVLGFDC ITTGYAYTQG LNGSVLSLLM GASAVSGICG TVAFTWIRKK
361: CGLIRTGFIA GVTQLSCLTL CVASVFAPGS PFDLSVSPFE EVLRHLFGDS GSLRESPTFI
421: PTTEPPIQAN VTVFEEAPPV ESYMSVGLLF AGVIAARVGL WSFDLTVTQL IQENVIESER
481: GVINGVQNSM NYLLDLLHFI MVILAPNPEA FGLLVIISVS FVAMGHMMYF RFAYKSLGSR
541: LFLFCSPEQK PDPNIPSLPN SV