2.A.112.1.12
Xkr9 of 650 aas. Catalyzes phosphatidyl serine flipping from the inner
leaflet to the outer leaflet of the cell membrane to signal appoptosis.
It has a C-terminal caspase recognition signal that may play an
important role. Xkr4, 8 and 9 have this activity and have several
essential residues in TMS2 and cytoplasmic loop 2 (Suzuki et al. 2014).
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| Accession Number: | Q5GH70 |
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| Protein Name: | XK-related protein 9 |
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| Length: | 373 |
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| Molecular Weight: | 43406.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 9 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
phospholipid, phosphatidyl-L-serine(1-) |
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1: MKYTKQNFMM SVLGIIIYVT DLIVDIWVSV RFFHEGQYVF SALALSFMLF GTLVAQCFSY
61: SWFKADLKKA GQESQHCFLL LHCLQGGVFT RYWFALKRGY HAAFKYDSNT SNFVEEQIDL
121: HKEVIDRVTD LSMLRLFETY LEGCPQLILQ LYILLEHGQA NFSQYAAIMV SCCAISWSTV
181: DYQVALRKSL PDKKLLNGLC PKITYLFYKL FTLLSWMLSV VLLLFLNVKI ALFLLLFLWL
241: LGIIWAFKNN TQFCTCISME FLYRIVVGFI LIFTFFNIKG QNTKCPMSCY YIVRVLGTLG
301: ILTVFWVCPL TIFNPDYFIP ISITIVLTLL LGILFLIVYY GSFHPNRSAE TKCDEIDGKP
361: VLRECRMRYF LME