TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.12.1.1









ATP:ADP antiporter (transports ATP and ADP but not dATP, dADP, ddATP or ddADP), Tlc1 (Daugherty et al., 2004)
Bacteria
Pseudomonadota
ATP/ADP translocase (Tlc1) of Rickettsia prowazekii (spP19568)
2.A.12.1.2









ATP:ADP antiporter, Npt1 (Tjaden et al. 1999).  Also transports NAD as a preferred substrate (Fisher et al. 2013).

Bacteria
Chlamydiota
Npt1 of Chlamydia trachomatis (gbAE001281)
2.A.12.1.3









Nucleotide antiporter (binds and probably transports ATP, dATP, ddATP, ADP, dADP and ddADP (deoxy on the sugar moiety) but not AMP, UTP, CTP or GTP) (Daugherty et al., 2004)
Bacteria
Proteobacteria
Nucleotide antiporter of Caedibacter caryophilus (CAD29686)
2.A.12.1.4









The nucleotide (CTP, UTP, GDP) (GTP inhibits but is not transported) (Audia and Winkler, 2006)
Bacteria
Pseudomonadota
Tlc4 of Rickettsia prowazekii (Q9ZD47)
2.A.12.1.5









The GTP/GDP transporter, Tlc5 (Audia and Winkler, 2006)
Bacteria
Pseudomonadota
Tlc5 of Rickettsia prowazekii (O05962)
2.A.12.1.6









Bacteria
Chlamydiota
Ntt1 of Candidatus protochlamydia amoebophila (Q6MEM5)
2.A.12.1.7









NTP (all four ribonucleoside triphosphates) antiporter, Ntt2 (Haferkamp et a;., 2006)
Bacteria
Chlamydiota
Ntt2 of Candidatus protochlamydia amoebophila (Q6MEN4)
2.A.12.1.8









UTP:H+ symporter, Ntt3 (Haferkamp et al., 2006)
Bacteria
Chlamydiota
Ntt3 of Candidatus protochlamydia amoebophila (Q6MEN5)
2.A.12.1.9









GTP/ATP:H+ symporter, Ntt5 (Haferkamp et al., 2006)
Bacteria
Chlamydiota
Ntt5 of Candidatus protochlamydia amoebophila (Q6MBI2)
2.A.12.1.10









The microsporidial ATP/ADP exchanger, NTT1 (Km= 11μM; cell surface localized when in the host cell; Tsaousis et al. 2008).
Eukaryota
Fungi, Microsporidia
NTT1 of Encephalitozoon cuniculi (Q8SRA2)
2.A.12.1.11









The microsporidial ATP/ADP exchanger, NTT2 (Km= 20μM; present in spores; localized to the cell surface; Tsaousis et al., 2008).
Eukaryota
Fungi, Microsporidia
NTT2 of Encephalitozoon cuniculi (Q8SUF9)
2.A.12.1.12









The microsporidial ATP/ADP exchanger, NTT3 (Km= 24μM; present in mitosomes; Tsaousis et al., 2008).
Eukaryota
Fungi, Microsporidia
NTT3 of Encephalitozoon cuniculi (Q8SUG0)
2.A.12.1.13









The microsporidial ATP/ADP exchanger, NTT4 (Km= 2μM; present on the cell surface when in the host cell; Tsaousis et al., 2008).
Eukaryota
Fungi, Microsporidia
NTT4 of Encephalitozoon cuniculi (Q8SUG7)
2.A.12.1.14









The nucleotide (ATP/ADP) exchanger NTT1 (Schmitz-Esser et al., 2008) (KMs for ATP and ADP ~ 250 μM)
Bacteria
Thermodesulfobacteriota
NTT1 of Lawsonia intracellularis (B0RZB7)
2.A.12.1.15









High affinity ATP/ADP antiporter of 469 aas and 12 TMSs, NttA.  Probably also transporters other nucleotides with low affinity (Vahling et al. 2010).

Bacteria
Pseudomonadota
NttA of Liberibacter asiaticus (Citrus greening disease) (Liberobacter asiaticum)
2.A.12.1.16









ATP:ADP antiporter of 624 aas and 12 TMSs, AATP1. Transports ATP and ADP in a counterflow reaction.  The apparent Km value for ATP was reported to be 28 μM (Neuhaus et al. 1997). In Solanum tuberosum (potato), inhibition of the orthologous AATP1 transporter resulted in greater resistance to the soft rot-causing pathogen, Erwinia carotovora subsp. atroseptica (Linke et al. 2002) and the pathogenic fungus, Alternaria solani (Conrath et al. 2003).

Eukaryota
Viridiplantae, Streptophyta
Adenylate translocator-1 (AATP1) of Arabidopsis thaliana (gbZ49227)
2.A.12.1.17









Nucleoside triphosphate:H+ symporter.  Transports ATP, GTP, CTP and UTP (Tjaden et al. 1999).

Bacteria
Chlamydiota
Npt2 of Chlamydia trachomatis (gbAE001323)
2.A.12.1.18









NAD+:ADP antiporter, Ntt4 (Haferkamp et al., 2006)
Bacteria
Chlamydiota
Ntt4 of Candidatus Protochlamydia amoeboophila (Q6MDZ0)
2.A.12.1.19









Chloroplast inner envelope ATP/ADP antiporter, AATP2, of 618 aas and 12 TMSs. The apparent Km values for ATP and ADP were reported to be 22 μM and 20 μM, respectively. (Möhlmann et al. 1998).

Eukaryota
Viridiplantae, Streptophyta
AATP2 of Arabidopsis thaliana (Mouse-ear cress)
2.A.12.2.1









AAA family homologue of 927 aas with an N-terminal 12 TMS MFS domain and a C-terminal fairly hydrophilic "lipodomain" not recognized by CDD.

Bacteria
Chlamydiota
AAA family homologue of Chlamydia trachomatis
2.A.12.2.2









AAA family member of 878 aas with an N-terminal 12 TMS MFS domain and a long (~450 aa) hydrophilic extension containing at least one internal HEAT_2 domain.

Bacteria
Pseudomonadota
AAA family member of Novosphingobium sp. PP1Y