2.A.18.9.2
SLC38A9 of 549 aas and 111 TMSs. The crystal structure of this lysosomal transporter with arginine bound in the inward facing conformation has been solved (Lei et al. 2018). The bound arginine was locked in a transitional state stabilized by TMS1, which was anchored at the groove between TM5 and TM7. These anchoring interactions were mediated by the highly conserved WNTMM motif in TMS1, and mutations in this motif abolished arginine transport (Lei et al. 2018).
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| Accession Number: | Q08BA4 |
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| Protein Name: | Sodium-coupled neutral amino acid transporter 9 |
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| Length: | 549 |
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| Molecular Weight: | 61897.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Lysosome membrane1 / Multi-pass membrane protein2 |
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| Substrate |
amino acid, arginine |
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1: MDEDSKPLLG SVPTGDYYTD SLDPKQRRPF HVEPRNIVGE DVQERVSAEA AVLSSRVHYY
61: SRLTGSSDRL LAPPDHVIPS HEDIYIYSPL GTAFKVQGGD SPIKNPSIVT IFAIWNTMMG
121: TSILSIPWGI KQAGFTLGII IIVLMGLLTL YCCYRVLKST KSIPYVDTSD WEFPDVCKYY
181: FGGFGKWSSL VFSLVSLIGA MVVYWVLMSN FLFNTGKFIF NYVHNVNTSD AFGTNGTERV
241: ICPYPDVDPH GNSSTSLYSG SDNSTGLEFD HWWSKTNTIP FYLILLLLPL LNFRSASFFA
301: RFTFLGTISV IYLIFLVTYK AIQLGFHLEF HWFDSSMFFV PEFRTLFPQL SGVLTLAFFI
361: HNCIITLMKN NKHQENNVRD LSLAYLLVGL TYLYVGVLIF AAFPSPPLSK ECIEPNFLDN
421: FPSSDILVFV ARTFLLFQMT TVYPLLGYLV RVQLMGQIFG NHYPGFLHVF VLNVFVVGAG
481: VLMARFYPNI GSIIRYSGAL CGLALVFVLP SLIHMVSLKR RGELRWTSTL FHGFLILLGV
541: ANLLGQFFM