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2.A.22.1.4
Antidepressant- and cocaine-sensitive dopamine transporter, T23G5.5 (Km for dopamine, 1.2 µM; dependent on extracellular Na+ and Cl-; blocked by cocaine and D-amphetamine) (Jayanthi et al. 1998) (interacts with syntaxin 1A to regulate channel activity and dopaminergic synaptic transmission; Carvelli et al., 2008).  It is blocked by the neurotoxins 6-hydroxydopamine (6-OHDA) and 1-methyl-4-phenylpyridinium ion, and neuron-specific toxin suppressor mutants have been isolated (Nass et al. 2005).  Amphetamine exposure during embryogenesis changes expression and function of the dopamine transporter in Caenorhabditis elegans offspring (Ambigapathy et al. 2024).

Accession Number:Q03614
Protein Name:Sodium-dependent dopamine transporter aka DAT-1 aka T23G5.5
Length:615
Molecular Weight:69266.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate chloride, sodium(1+), dopamine

Cross database links:

DIP: DIP-46293N
RefSeq: NP_499043.1   
Entrez Gene ID: 176304   
Pfam: PF00209   
KEGG: cel:T23G5.5   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005328 F:neurotransmitter:sodium symporter activity
GO:0006836 P:neurotransmitter transport

References (3)

[1] “The Caenorhabditis elegans gene T23G5.5 encodes an antidepressant- and cocaine-sensitive dopamine transporter.”  Jayanthi L.D.et.al.   9765501
[2] “2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.”  Wilson R.et.al.   7906398
[3] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MQLVPTDDPD EKIGRTSNGM QNATLPIDGP VNTEPKDPAR EQWSGKLDFL LSVVGFAVDL 
61:	GNIWRFPYLC FKNGGGVFLI PYSIMVLLTG VPLFYMELCL GQYYRKGAIT TWGRICPLFK 
121:	GIGYCVILTA FYVDFFYNVI LAWGLHYLYT SFSFNLPWAS CNNSYNSPAC YEPHWSEDGT 
181:	AMCRSANQSV SAEKISAAEE YFYKGFLGLH EANAPNSHVI RSVTDLGNVR WDIALSLFVV 
241:	YLICYFSMWK GIHTSGKVVW FTALFPYVVL GILFIRGVTL PGWQNGIEYY LRPNFEMLKR 
301:	PSVWQDAATQ VFFSLGPGFG VLMAYSSYND FHNNVYVDAL FTSFINCATS FLSGFVIFSV 
361:	LGYMSCKSGK PIEAVAQEGP GLVFVVYPEA LSTMPYAPFW SVLFFLMLMT LGLDSSFGGS 
421:	EAIITGLSDE FPILKKNREV FVGCLFAFYM VIGIAMCTEG GILIMEWLII YGTTWGLLIA 
481:	VFCEAMVIAY IYGLRQFVHD VKEMMGFRPG NYWKFCWSCA APFILLSMIT SNFINYQALT 
541:	YQDYTYPTAA NVIGIIFALS GASFIPLVGI YKFVNARGNT ISEKWQRVTM PYRKRPNQTE 
601:	YIPIPTTQPH SDIML