| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
2.A.27.1.1 | Glutamate:Na+ symporter, GltS, of 401 aas and 12 TMSs. It transports L- and D-glutamate, α-methylglutamate and homocysteate. Swapping the order of the two halves (repeat units) does not decrease activity (Dobrowolski and Lolkema, 2010). | Bacteria |
Pseudomonadota | GltS of E. coli (P0AER8) |
|
2.A.27.1.2 | Glutamate:Na | Bacteria |
Cyanobacteriota | GltS of Synechocystis PCC6803 |
|
2.A.27.1.3 | Probable L-glutamate/N-acetylglutamate uptake porter, GltS. Involved in N-acetylglutamate catabolism as a carbon and nitrogen source (Johnson et al. 2008). | Bacteria |
Pseudomonadota | GltS of Pseudomonas aereuginosa |
|
2.A.27.1.4 | Sodium/glutamate symporter, GltS, YbfA, JemA, of 401 aas and 12 TMSs. Note, the Na+:Glutamate symporter with TC# 2.A.27.1.1 is also called GltS. YbfA regulates the sensitivity of E. coli K12 to plantaricin BM-1 via the BasS/BasR two- component regulatory system (Chen et al. 2021). | Bacteria |
Pseudomonadota | GltS of E. coli |
|
2.A.27.1.5 | sodium:glutamate symporter of 476 aas and 12 TMSs, GltS. It has a Km for glutamate of 5 μM, but has low affinity for Na+. Glutamate uptake is inhibited by glu, gln, asp and asn (Boonburapong et al. 2012). | Bacteria |
Cyanobacteriota | GltS |
|
2.A.27.1.6 | Na2+:glutamate symporter, GltS, of 401 aas and 12 TMSs in a 6 + 6 TMS arrangement, functioning with a periplasmic L-glutamate binding protein (Jaques et al. 2025). BP0403 binds L-glutamate with nanomolar affinity. Genome context analysis of BP0403 reveals no TRAP membrane component genes; instead, it co-localizes with translational coupling with gltS, encoding a Na+/glutamate symporter. In other bacteria, fused BP0403-GltS homologues, strongly suggesting that this constitutes a completely novel SBP-dependent secondary active transporter. Structural comparisons suggest GltS operates by an elevator-type mechanism, like TRAP transporters; the association of an SBP with this class of secondary transporter is a novel theme (Jaques et al. 2025). | None |
Pseudomonadati, Pseudomonadota | GltS with a periplasmic L-glutamate BP of Bordetella pertussis |
|
2.A.27.1.7 | Fused L-glutamate periplasmic binding protein (N-terminal (residues 1 - 306) followed by a 12 TMS integral membrane GltS transporter domain (residues 325 - 712). It is probably a heterotetramer (Jaques et al. 2025). | None |
Bacillati, Bacillota | Fused BP0403-like domain (N-terminal) - GltS (C-terminal) of Lachnoanerobaculum gingivalis |
|
2.A.27.1.8 | Fused L-glutamate periplasmic binding protein (N-terminal (residues 1 - 306) followed by a 12 TMS integral membrane GltS transporter domain (residues 325 - 712). It is probably a heterotetramer (Jaques et al. 2025). | None |
Metazoa, Chordata | Fused BP0403-like domain (N-terminal) - GltS of Lachnoanerobaculum saburreum |
|
2.A.27.2.1 | Glutamate:sodium symporter, GltS (Boonburapong et al. 2012). | Bacteria |
Cyanobacteriota | GltS of Snyechococcus sp. ATCC27264 (Agmenellum guadruplicatum) |
|
2.A.27.2.2 | Archaea |
Euryarchaeota | GltS of Methanosarcina mazei |