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| Accession Number: | Q9UJS0 |
| Protein Name: | CMC2 aka SLC25A13 or ARALAR2 |
| Length: | 675 |
| Molecular Weight: | 74176.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Mitochondrion inner membrane1 / Multi-pass membrane protein2 |
| Substrate | calcium(2+), glutamate(2-), aspartate(2-) |
Cross database links:
| RefSeq: | NP_055066.1 |
|---|---|
| Entrez Gene ID: | 10165 |
| Pfam: | PF00153 |
| OMIM: |
603471 phenotype 603859 gene 605814 phenotype |
| KEGG: | hsa:10165 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005743
C:mitochondrial inner membrane
GO:0005509
F:calcium ion binding
GO:0015183
F:L-aspartate transmembrane transporter activity
GO:0005313
F:L-glutamate transmembrane transporter activity
GO:0015810
P:aspartate transport
GO:0006754
P:ATP biosynthetic process
GO:0015813
P:L-glutamate transport
GO:0043490
P:malate-aspartate shuttle
GO:0051592
P:response to calcium ion
GO:0055085
P:transmembrane transport
GO:0006094
P:gluconeogenesis
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References (17)[1] “The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein.” Kobayashi K.et.al. 10369257 [2] “Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissues.” Del Arco A.et.al. 10642534 [3] “The DNA sequence of human chromosome 7.” Hillier L.W.et.al. 12853948 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Genomic structure of the adult-onset type II citrullinemia gene, SLC25A13, and cloning and expression of its mouse homologue.” Sinasac D.S.et.al. 10610724 [6] “Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria.” Palmieri L.et.al. 11566871 [7] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.” Choudhary C.et.al. 19608861 [8] “Screening of SLC25A13 mutations in early and late onset patients with citrin deficiency and in the Japanese population: identification of two novel mutations and establishment of multiple DNA diagnosis methods for nine mutations.” Yamaguchi N.et.al. 11793471 [9] “The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein.” Kobayashi K.et.al. 10369257 [10] “Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissues.” Del Arco A.et.al. 10642534 [11] “Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria.” Palmieri L.et.al. 11566871 [12] “The DNA sequence of human chromosome 7.” Hillier L.W.et.al. 12853948 [13] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [14] “Genomic structure of the adult-onset type II citrullinemia gene, SLC25A13, and cloning and expression of its mouse homologue.” Sinasac D.S.et.al. 10610724 [15] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.” Choudhary C.et.al. 19608861 [16] “Initial characterization of the human central proteome.” Burkard T.R.et.al. 21269460 [17] “Screening of SLC25A13 mutations in early and late onset patients with citrin deficiency and in the Japanese population: identification of two novel mutations and establishment of multiple DNA diagnosis methods for nine mutations.” Yamaguchi N.et.al. 11793471
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| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAAAKVALTK RADPAELRTI FLKYASIEKN GEFFMSPNDF VTRYLNIFGE SQPNPKTVEL 61: LSGVVDQTKD GLISFQEFVA FESVLCAPDA LFMVAFQLFD KAGKGEVTFE DVKQVFGQTT 121: IHQHIPFNWD SEFVQLHFGK ERKRHLTYAE FTQFLLEIQL EHAKQAFVQR DNARTGRVTA 181: IDFRDIMVTI RPHVLTPFVE ECLVAAAGGT TSHQVSFSYF NGFNSLLNNM ELIRKIYSTL 241: AGTRKDVEVT KEEFVLAAQK FGQVTPMEVD ILFQLADLYE PRGRMTLADI ERIAPLEEGT 301: LPFNLAEAQR QKASGDSARP VLLQVAESAY RFGLGSVAGA VGATAVYPID LVKTRMQNQR 361: STGSFVGELM YKNSFDCFKK VLRYEGFFGL YRGLLPQLLG VAPEKAIKLT VNDFVRDKFM 421: HKDGSVPLAA EILAGGCAGG SQVIFTNPLE IVKIRLQVAG EITTGPRVSA LSVVRDLGFF 481: GIYKGAKACF LRDIPFSAIY FPCYAHVKAS FANEDGQVSP GSLLLAGAIA GMPAASLVTP 541: ADVIKTRLQV AARAGQTTYS GVIDCFRKIL REEGPKALWK GAGARVFRSS PQFGVTLLTY 601: ELLQRWFYID FGGVKPMGSE PVPKSRINLP APNPDHVGGY KLAVATFAGI ENKFGLYLPL 661: FKPSVSTSKA IGGGP