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| Accession Number: | P55013 |
| Protein Name: | NKC1 aka SLC12A2 or NKCC1 |
| Length: | 1191 |
| Molecular Weight: | 129775.00 |
| Species: | Squalus acanthias (Spiny dogfish) [7797] |
| Number of TMSs: | 11 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | |
Cross database links:
| Pfam: | PF00324 PF08403 |
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Gene Ontology
GO:0016021
C:integral to membrane
GO:0015377
F:cation:chloride symporter activity
GO:0006821
P:chloride transport
GO:0006813
P:potassium ion transport
GO:0006814
P:sodium ion transport
GO:0055085
P:transmembrane transport
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References (1)[1] “Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter.” Xu J.-C.et.al. 8134373
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MEPAFPASSA GVQSQSGPEP GAGQQEPPPP ATPLRPVASQ SRFQVDLVTE GGGGGDGQKG 61: QTAAQPAAAA KDKDRGDGGA AAPSPASPAA AAEPPAAAAE EAKGRFRVNF VDPASDEPPL 121: SSQQQPPPPS SASSAHGGHQ PPSESMNGYP QNGDTMMSEG SLHSSGTGAH HYYDTHTNTY 181: YLRTFGHNTI DAVPRIDHYR HTVAQLGEKL IRPSLAELHD ELDKEPFEDG YVNGEESSPA 241: EEAVSKHVAD NKGVVKFGWI KGVLVRCMLN IWGVMLFIRL SWIVGHAGIG LALLVIGTAT 301: VVTTITGLST SAITTNGFVR GGGAYYLISR SLGPEFGGAI GLIFAFANAV AVAMYVVGFA 361: ETVRDLLVEH NALMIDEMSD IRIIGSVTIV VLFGISVAGM EWEAKAQIVL LGILLLAIVN 421: FTVGTFIPAN DKRAKGFFNY RGEIFSENFV PDFRDGEDFF SVFAIFFPAA TGILAGANIS 481: GDLADPQLAI PKGTLLAILI TTIVYAGAAV SVGSCIVREA TGNLTDAIIP GTVTNCTNVA 541: CKLGFNFSSC ATNKCSYGLM NDFQVMSLVS GFGPLITAGI FSATLSSALA SLVSAPKIFQ 601: ALCKDNIYPG LHVFSVGYGK NNEPLRGYVL TFFIGLGFIL IAELNVIAPI ISNFFLASYA 661: LINFSVFHAS LAKSPGWRPA FRFYNMWISL IGAILCCGVM FVINWWAALL TNVIVLALYI 721: YVTYKKPDVN WGSSTQALTY LNALQHAIRL TGVEDHVKNF RPQCLLMTGA PTSRPALLHL 781: VHAFTKNVGL VVCGHVHTGP RRQALKEIST DQAKYQRWLI KNKMKAFYAP VYAEDLREGT 841: QFLLQAVGLG RMRPNTLVFG FKKDWRQALM KDVENYINAI HDAFDYQYGV VVIRLKEGFN 901: ISHLQAQEEL CTSQEKSAHP KDIVVNLEHS DADSSKPSSK SVSETNSPAV CQDQKDEEDD 961: GKASTQPLLK KEVKDPSVPL NMTDQKLLQA SSQFQKKQGK GTIDVWWLFD DGGLTLLIPY 1021: LLTTKKKWKD CKIRVFIGGK INRIDHDRRT MATLLSKFRI DFSDITVLGD MNTKPSKDNI 1081: TAFEEMIEPF RLHEDDKEQE ASEKMKEEEP WRITDNELEI YRMKTYRQIR LNELLRENSG 1141: TANLIVMSLP VARKGAVSSA LYMAWIETLS KDLPPILLVR GNHQSVLTFY S