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2.A.31.1.3
Anion exchange protein 3 (AE 3; AE3) (Anion exchanger 3) (CAE3/BAE3) (Cardiac/brain band 3-like protein) (Neuronal band 3-like protein) (Solute carrier family 4 member 3).  The motif LDADD is a binding site for the N-terminal basic region of carbonic ahnydride II (not I), facilitating bicarbonate transport (Moraes and Reithmeier 2012). An isoform of this Na+-independent Cl-/HCO3- exchanger is involved in myocardial pHi recovery from intracellular alkalization (Chiappe de Cingolani et al. 2006).

Accession Number:P48751
Protein Name:Anion exchange protein 3
Length:1232
Molecular Weight:135791.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate bicarbonate, anions

Cross database links:

Entrez Gene ID: 6508   
Pfam: PF07565    PF00955   
KEGG: hsa:6508   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005452 F:inorganic anion exchanger activity
GO:0015701 P:bicarbonate transport
GO:0051453 P:regulation of intracellular pH

References (5)

[1] “Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.”  Yannoukakos D.et.al.   7923606
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.”  Yu L.-R.et.al.   17924679

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL ISKPPAWDPE 
61:	KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP TSARHTRRKR KKEKTSAPPS 
121:	EGTPPIQEEG GAGVDEEEEE EEEEEGESEA EPVEPPHSGT PQKAKFSIGS DEDDSPGLPG 
181:	RAAVTKPLPS VGPHTDKSPQ HSSSSPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA 
241:	LGNPGGPEQQ VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG 
301:	LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED VEEETERWGK 
361:	PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV ETMIVSDQIR PEDRASVLRT 
421:	LLLKHSHPND DKDSGFFPRN PSSSSMNSVL GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP 
481:	HDPDAKEKPL HMPGGDGHRG KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV 
541:	LLESVLEVPV PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA 
601:	ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG GYTAPGKELS 
661:	LELGGSEATP EDDPLLRTGS VFGGLVRDVR RRYPHYPSDL RDALHSQCVA AVLFIYFAAL 
721:	SPAITFGGLL GEKTEGLMGV SELIVSTAVL GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK 
781:	FCRAQDLEYL TGRVWVGLWL VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF 
841:	YKLYKVFTEH PLLPFYPPEG ALEGSLDAGL EPNGSALPPT EGPPSPRNQP NTALLSLILM 
901:	LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY TQKLTVPTGL 
961:	SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI FMETQITALI VSQKARRLLK 
1021:	GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE 
1081:	QRVTGVLIAS LVGLSIVMGA VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH 
1141:	HPEQPYVTKV KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF 
1201:	QDRELQALDS EDAEPNFDED GQDEYNELHM PV