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|---|---|
| Accession Number: | Q6U841 |
| Protein Name: | Sodium-driven chloride bicarbonate exchanger |
| Length: | 1118 |
| Molecular Weight: | 125946.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 10 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | chloride, sodium(1+), hydrogencarbonate |
Cross database links:
| Entrez Gene ID: | 57282 |
|---|---|
| Pfam: | PF07565 PF00955 |
| KEGG: | hsa:57282 |
Gene Ontology
GO:0016323
C:basolateral plasma membrane
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0005452
F:inorganic anion exchanger activity
GO:0015293
F:symporter activity
GO:0015701
P:bicarbonate transport
GO:0006821
P:chloride transport
GO:0006885
P:regulation of pH
GO:0006814
P:sodium ion transport
GO:0055085
P:transmembrane transport
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References (5)[1] “The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization.” Wang C.-Z.et.al. 10993873 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI GVHVPLGGRK 61: SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ FILGTEDDDE EHIPHDLFTE 121: LDEICWREGE DAEWRETARW LKFEEDVEDG GERWSKPYVA TLSLHSLFEL RSCILNGTVL 181: LDMHANTLEE IADMVLDQQV SSGQLNEDVR HRVHEALMKQ HHHQNQKKLT NRIPIVRSFA 241: DIGKKQSEPN SMDKNAGQVV SPQSAPACVE NKNDVSRENS TVDFSKGLGG QQKGHTSPCG 301: MKQRHEKGPP HQQEREVDLH FMKKIPPGAE ASNILVGELE FLDRTVVAFV RLSPAVLLQG 361: LAEVPIPTRF LFILLGPLGK GQQYHEIGRS IATLMTDEVF HDVAYKAKDR NDLVSGIDEF 421: LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR KIPAVPNGTA AHGEAEPHGG HSGPELQRTG 481: RIFGGLILDI KRKAPYFWSD FRDAFSLQCL ASFLFLYCAC MSPVITFGGL LGEATEGRIS 541: AIESLFGASM TGIAYSLFGG QPLTILGSTG PVLVFEKILF KFCKEYGLSY LSLRASIGLW 601: TATLCIILVA TDASSLVCYI TRFTEEAFAS LICIIFIYEA LEKLFELSEA YPINMHNDLE 661: LLTQYSCNCV EPHNPSNGTL KEWRESNISA SDIIWENLTV SECKSLHGEY VGRACGHDHP 721: YVPDVLFWSV ILFFSTVTLS ATLKQFKTSR YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG 781: IPSPKLQVPS VFKPTRDDRG WFVTPLGPNP WWTVIAAIIP ALLCTILIFM DQQITAVIIN 841: RKEHKLKKGC GYHLDLLMVA VMLGVCSIMG LPWFVAATVL SITHVNSLKL ESECSAPGEQ 901: PKFLGIREQR VTGLMIFILM GSSVFMTSIL KFIPMPVLYG VFLYMGASSL KGIQFFDRIK 961: LFWMPAKHQP DFIYLRHVPL RKVHLFTIIQ MSCLGLLWII KVSRAAIVFP MMVLALVFVR 1021: KLMDLLFTKR ELSWLDDLMP ESKKKKLEDA EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS 1081: VINISDEMSK TALWRNLLIT ADNSKDKESS FPSKSSPS