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2.A.31.2.14
Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) of 1118 aas and 12 or 14 TMSs.  This protein and SLC4A1 (TC# 2.A.31.1.1) are down-regulated in Meniere's disease (Sun et al. 2018).

Accession Number:Q6U841
Protein Name:Sodium-driven chloride bicarbonate exchanger
Length:1118
Molecular Weight:125946.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate bicarbonate, Cl-, Na+

Cross database links:

Entrez Gene ID: 57282   
Pfam: PF07565    PF00955   
KEGG: hsa:57282   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005452 F:inorganic anion exchanger activity
GO:0015293 F:symporter activity
GO:0015701 P:bicarbonate transport
GO:0006821 P:chloride transport
GO:0006885 P:regulation of pH
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (5)

[1] “The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization.”  Wang C.-Z.et.al.   10993873
[2] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[5] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI GVHVPLGGRK 
61:	SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ FILGTEDDDE EHIPHDLFTE 
121:	LDEICWREGE DAEWRETARW LKFEEDVEDG GERWSKPYVA TLSLHSLFEL RSCILNGTVL 
181:	LDMHANTLEE IADMVLDQQV SSGQLNEDVR HRVHEALMKQ HHHQNQKKLT NRIPIVRSFA 
241:	DIGKKQSEPN SMDKNAGQVV SPQSAPACVE NKNDVSRENS TVDFSKGLGG QQKGHTSPCG 
301:	MKQRHEKGPP HQQEREVDLH FMKKIPPGAE ASNILVGELE FLDRTVVAFV RLSPAVLLQG 
361:	LAEVPIPTRF LFILLGPLGK GQQYHEIGRS IATLMTDEVF HDVAYKAKDR NDLVSGIDEF 
421:	LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR KIPAVPNGTA AHGEAEPHGG HSGPELQRTG 
481:	RIFGGLILDI KRKAPYFWSD FRDAFSLQCL ASFLFLYCAC MSPVITFGGL LGEATEGRIS 
541:	AIESLFGASM TGIAYSLFGG QPLTILGSTG PVLVFEKILF KFCKEYGLSY LSLRASIGLW 
601:	TATLCIILVA TDASSLVCYI TRFTEEAFAS LICIIFIYEA LEKLFELSEA YPINMHNDLE 
661:	LLTQYSCNCV EPHNPSNGTL KEWRESNISA SDIIWENLTV SECKSLHGEY VGRACGHDHP 
721:	YVPDVLFWSV ILFFSTVTLS ATLKQFKTSR YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG 
781:	IPSPKLQVPS VFKPTRDDRG WFVTPLGPNP WWTVIAAIIP ALLCTILIFM DQQITAVIIN 
841:	RKEHKLKKGC GYHLDLLMVA VMLGVCSIMG LPWFVAATVL SITHVNSLKL ESECSAPGEQ 
901:	PKFLGIREQR VTGLMIFILM GSSVFMTSIL KFIPMPVLYG VFLYMGASSL KGIQFFDRIK 
961:	LFWMPAKHQP DFIYLRHVPL RKVHLFTIIQ MSCLGLLWII KVSRAAIVFP MMVLALVFVR 
1021:	KLMDLLFTKR ELSWLDDLMP ESKKKKLEDA EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS 
1081:	VINISDEMSK TALWRNLLIT ADNSKDKESS FPSKSSPS