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2.A.31.2.6
The Na+-dependent Cl-/HCO3- exchanger, NDAE1 (Romero et al., 2000)

Accession Number:Q9VM32
Protein Name:Na+ driven anion exchanger NDAE1
Length:1030
Molecular Weight:115007.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cl-, bicarbonate

Cross database links:

RefSeq: NP_523501.1   
Entrez Gene ID: 34005   
Pfam: PF07565    PF00955   
KEGG: dme:Dmel_CG4225   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005452 F:inorganic anion exchanger activity
GO:0005515 F:protein binding
GO:0015701 P:bicarbonate transport
GO:0006821 P:chloride transport
GO:0015992 P:proton transport
GO:0006814 P:sodium ion transport

References (3)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[3] “Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter.”  Romero M.F.et.al.   10827195

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MAEKNEYIEL PWTMNSSSGD DEAPKDPRTG GEDFTQQFTE NDFEVTPPAQ RVQFILGEDV 
61:	DDGTHVSHPL FSEMGMLVKE GDEIEWKETA RWIKFEEDVE EGGNRWSKPH VATLSLHSLF 
121:	ELRRLLVNGS VMLDMEAQNL EVMADLVCDH MVSAGTLPPG VKDKVKDALL RRHRHQHEYA 
181:	KKTRLPIIRS LADMRNHSSS KKKKSNSKHS RPAQNLSSIT EDMVKSPSNQ SMARPGSGTE 
241:	LSEQQHKGNT HFMRKIPPGA EASNILVGEV DFLERTLSCF IRLSQAVVLG DLTEVPVPTR 
301:	FVFILLGPPG SQSNFHEIGR AMATLMSDEI FHEVAYRARK RDHLLSGVDE FLDAVTVLPP 
361:	GEWDPTIRIE PPAAIPSQEV RKRPPELPKE EVDEEEEEAR LREENGLSRT GRLFGGLIND 
421:	IKRKAPWYIS DYKDALSMQC VASWIFLYFA CLSPIITFGG LLAEATGKHM AAMESLVSGF 
481:	VCGMGYGFFS GQPLTILGST GPVLVFESII YEFCLKMGWD YMTFRFWIGM WVAGICIVLT 
541:	AIDASALVCY ITRFTEENFA TLIAFIFIYK AIENVMVIGK NFPVNQGIYD CVCTPPIGSN 
601:	ASVIDYAKYN WDSCESYNGT LVGGDCGTPP TENVFLMSVV LCAGTFLIST VLKEFKNALF 
661:	FPSIVRQYIS DFSVLIAIFA MSFFDYSLGV PTQKLEVPNE LKPTLSTRGW LIPPFVEKNP 
721:	WWSAIIAVFP ALLGTILIFM DQQITAVIVN RKENKLKKGC GYHLDLFILS ILIAICSMMG 
781:	LPWFVAATVL SINHVNSLKL ESECSAPGEK PQFLGVREQR VTHILIFLTI GVSVLLTPLL 
841:	GNIPMPVLFG VFLYMGVASL KGLQFFDRIL IMFMPAKYQP DYMFLRQVPI KRVHLFTMIQ 
901:	LACLIILWLI KSFSQTSILF PLMLVVMIGI RKALDLVFTR RELKILDDIM PEMTKRAAAD 
961:	DLHKLDAEVG LLARIFPWGK GSRSRVVTKP PGLDDGIVGS GGAVGAGLIT CTTSNANEKE 
1021:	FEAQSSLLKK