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Accession Number: | Q8R4H8 |
Protein Name: | NHE aka Chloride-dependent sodium/hydrogen exchanger |
Length: | 438 |
Molecular Weight: | 48482.00 |
Species: | Rattus norvegicus (Rat) [10116] |
Number of TMSs: | 9 |
Location1 / Topology2 / Orientation3: | Cell inner membrane1 / Multi-pass membrane protein2 |
Substrate | sodium(1+), hydron |
Cross database links:
Pfam: | PF00999 |
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Gene Ontology
GO:0016323
C:basolateral plasma membrane
GO:0016021
C:integral to membrane
GO:0045121
C:membrane raft
GO:0015385
F:sodium:hydrogen antiporter activity
GO:0008134
F:transcription factor binding
GO:0030154
P:cell differentiation
GO:0016049
P:cell growth
GO:0045768
P:positive regulation of anti-apoptosis
GO:0007243
P:intracellular protein kinase cascade
GO:0006885
P:regulation of pH
GO:0042493
P:response to drug
GO:0014070
P:response to organic cyclic substance
GO:0006814
P:sodium ion transport
GO:0055085
P:transmembrane transport
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References (1)[1] “Cloning and expression of a chloride-dependent Na+-H+ exchanger.” Sangan P.et.al. 11773056
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External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MMLRWSGIWG LYPPRIFPSL LVVVALVGLL PVLRSHGLQL NPTASTIRGS EPPRERSIGD 61: VTTAPSEPVH HPDDRNLTNL YIEHGAKPVR KAFPVLDIDY LHVRTPFEIS LWILLACLMK 121: IGFHVIPTIS SIVPESCLLI VVGLLVGGLI KGVGETPPFL QSDVFFLFLL PPIILDAGYF 181: LPLRQFTENL GTILIFAVVG TLWNAFFLGG LLYAVCLVGG EQINNIGLLD TLLFGSIISA 241: VDPVAVLAVF EEIHINELLH ILVFGESLLN DAVTVVLYHL FEEFASYEYV GISDIFLGFL 301: SFFVVSLGGV FVGVVYGVIA AFTSRFTSHI RVIEPLFVFL YSYMAYLSAE LFHLSGIMAL 361: IASGVVMRPY VEANISRPLH AVPVLAGIVP QMIVQKNRID LNRRAFTPFF KQLHKTVPDQ 421: LDTPNRATSN FHFLFISI