TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.37.1.11
Transmembrane and coiled-coil domain 3, TMCO3, of 677 aas and 13 TMSs in a 1 (N-terminus) + 4 + 2 + 2 + 4 TMS (residues 255 - 670) arrangement.  When mutated, it causes cornea guttata and anterior polar cataracts (Chen et al. 2016).  The encoding gene is expressed in the human cornea, lens capsule, and choroid-retinal pigment epithelium (Chen et al. 2016). It is a prognostic biomarker that correlates with immune infiltration in hepatocellular carcinoma (Deng et al. 2021).

Accession Number:Q6UWJ1
Protein Name:Transmembrane and coiled-coil domain-containing protein 3
Length:677
Molecular Weight:75598.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MKVLGRSFFW VLFPVLPWAV QAVEHEEVAQ RVIKLHRGRG VAAMQSRQWV RDSCRKLSGL 
61:	LRQKNAVLNK LKTAIGAVEK DVGLSDEEKL FQVHTFEIFQ KELNESENSV FQAVYGLQRA 
121:	LQGDYKDVVN MKESSRQRLE ALREAAIKEE TEYMELLAAE KHQVEALKNM QHQNQSLSML 
181:	DEILEDVRKA ADRLEEEIEE HAFDDNKSVK GVNFEAVLRV EEEEANSKQN ITKREVEDDL 
241:	GLSMLIDSQN NQYILTKPRD STIPRADHHF IKDIVTIGML SLPCGWLCTA IGLPTMFGYI 
301:	ICGVLLGPSG LNSIKSIVQV ETLGEFGVFF TLFLVGLEFS PEKLRKVWKI SLQGPCYMTL 
361:	LMIAFGLLWG HLLRIKPTQS VFISTCLSLS STPLVSRFLM GSARGDKEGD IDYSTVLLGM 
421:	LVTQDVQLGL FMAVMPTLIQ AGASASSSIV VEVLRILVLI GQILFSLAAV FLLCLVIKKY 
481:	LIGPYYRKLH MESKGNKEIL ILGISAFIFL MLTVTELLDV SMELGCFLAG ALVSSQGPVV 
541:	TEEIATSIEP IRDFLAIVFF ASIGLHVFPT FVAYELTVLV FLTLSVVVMK FLLAALVLSL 
601:	ILPRSSQYIK WIVSAGLAQV SEFSFVLGSR ARRAGVISRE VYLLILSVTT LSLLLAPVLW 
661:	RAAITRCVPR PERRSSL