2.A.39.3.11
Purine/uracil uptake porter of 599 aas and 12 TMSs, NCS1 or PLUTO. Nucleobase:proton symporter that facilitates the uptake of nucleobases in the cells. Can transport adenine, guanine and uracil (Witz et al. 2014). Contributes to uracil import into plastids for plastidic uracil salvage which is essential for plant growth and development (Witz et al. 2012).
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| Accession Number: | Q9LZD0 |
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| Protein Name: | Purine-uracil permease NCS1 |
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| Length: | 599 |
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| Molecular Weight: | 65356.00 |
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| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Plastid1 |
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| Substrate |
hydron, adenine, guanine, uracil |
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1: MVSNCLSLSL HLNLHPHKHN RHSLSSLRSR TKAKLYQHVS FTDSSHKSSY TSCVSTFDIQ
61: RKSSKHYELG KHSFSPILPG DNLVLSRSGV IRPRLSAMTG SEINDHGYDE SQFDPSLTND
121: DLKPTTPSQR TFSWLDMSSL WIGLVVGVPT YYLAGSLVDL GMAWWQGIAT VVTANLILLV
181: PLVLTAQPGT LYGISFPVLA RSSFGIRGAH IPTLLRALVG CGWYGIETWI GGEAIFLLLP
241: GHIKKSALSH TLPWLGTSPL EFSCFIVFWL AQLCIVWRGM DGIRKLEKYS APILISLTSC
301: LLAWSYLKAG GFGHMLSLSS KLTSAQFWTL FFPSLTANIS FWATLALNIP DFSRFAKSQT
361: DQIIGQVGLP VFMGLFTFVG VAVTSSTSII FGRVISNPIE LLGQIGGLAT TLLAIVGISL
421: ATLTTNIAAN VVAPANALVN LNPKFFTFGR GAFLTAVLGI VFQPWRLLKS SESFVYTWLI
481: GYSALLGPIG GIILVDYYLI KKMKLNIGDL YSLSPSGEYY FSKGYNVAAV VALVAGIIPV
541: VPGFLHKISA LSKISNGFVV VYDNALFFSF IIAGFVYWII MSRLGRKQSS LSSSSHPLL