2.A.39.3.12
NCS1 of 540 aas and 12 TMSs. Transports adenine, guanine, hypoxanthine, cytosine, and allantoin and competitively binds xanthine and uric acid. The closely related Zea mays NCS1 transports
adenine, guanine, and cytosine and competitively binds,
5-fluorocytosine, hypoxanthine, xanthine, and uric acid. The differences
in these NCS1 profiles are due to a limited number of amino acid differences (Rapp et al. 2016).
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| Accession Number: | V9SBV7 |
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| Protein Name: | Nucleobase cation symporter 1 |
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| Length: | 540 |
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| Molecular Weight: | 56930.00 |
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| Species: | Setaria viridis (Green bristlegrass) [4556] |
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| Number of TMSs: | 12 |
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| Substrate |
cytosine, allantoin, adenine, guanine, 7,9-dihydro-1H-purine-2,6,8(3H)-trione, hypoxanthine, 9H-xanthine, flucytosine |
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1: MAMSMAMSKA ITARHATHLQ HRLVASSSQA APRLPLLPRR PSLALTVASP PRRLLPASPR
61: SSSSESDLAP TPPSERTMTA WDLASLWVGL VVGVPSYYLA GSLVDLGMSA LQGVATVAFA
121: NLIVLVTLVL TAAPAVTHGL PFPVLARAAF GVRGAHVPAV IRALVGCGWF GIESWIGGRA
181: IFLLLPSRLK SYQPLLAPVP GLGAAPLEFA CFLAFWAAQL GVIMRGMEGI RKLEKFAAPV
241: LFVLTSALLA WAYTSAGGFG RILSLPPRLT GAEFRKVFFP SLTANISFWA TVAINIPDFA
301: RYARSQADQV LGQAGLPVFM GMFTFAGLAI TSATEAIFGH VVSDPIELLG RIGGPVTTFL
361: AIFGIGLATI TTNIAANVVA PANALVSMSP RRFTFAKGAL VTALLGIAFQ PWRLLSSSES
421: FVYTWLLGYS ALMGPIGGVI LADHYIVRRT ALDVDALYSE DSGSPYYFQN GFNVAAMAAM
481: AAGVAPIVPG FLQKVGVLPS VSKAFATAYN NAWFVSFFVA GAVYCLLCGR GGVQAKQHSN