2.A.39.3.15
Uptake porter for allantoin, uric acid (urate) and uracil and related analyogues, FurE of 527 aas and 12 TMSs. Evidence has been presented that both the C- and/or N-terminal domains are involved in intramolecular dynamics critical for substrate selection (Papadaki et al. 2017). The last two TMSs in the APC-type FurE transporter act as an intramolecular chaperone, essential for concentrative ER-exit (Pyrris et al. 2024).
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| Accession Number: | Q5ATG4 |
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| Protein Name: | Uncharacterized protein |
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| Length: | 527 |
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| Molecular Weight: | 57479.00 |
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| Species: | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) [227321] |
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| Number of TMSs: | 12 |
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| Substrate |
allantoin, uracil, 7,9-dihydro-1H-purine-2,6,8(3H)-trione |
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1: MGLRERLQVK QGDASLATEA VASNKDLDPI PLDSPKRTWR WPSLLGFWVA EAFSISMYQV
61: TSTSVSKGLS APMAIAAVVV GHILVCIPAM LDGYVGAIFG INFPVYTRAS FGMKGSYFAV
121: FVRGIVAIIW FGTQTYQAGQ CVSTMLSAIW PSFNHFPNHL PSSGPITSAE LLCFFLAIIL
181: QAPLLWLKVS KLRYLFIVKT CIMPIFGIVL FAWAVKAANG FGPVFSKPSK ITDGTPVAVV
241: FLQCVTSAIG PKATLALNMP DFTRYAKTPR EVFWTQAVGL VVLVSLCGVL GATVSSASEV
301: IYGVQTWNPL EVAVLWNNRA AQFFAAFCWC LAAIGTNISA NSVSFSNDLA LWFPKYVDTR
361: RGAYICALLS ILSMPWYIQN SAASFSSFLG GYSLFLGAIA GVIVVDYWVC RGRRLRLRSL
421: YEAHGTHYFT KGVNIRAMIS FVCGIAPNLP GLAAVTGQDG VPKGANYLYS CSWLVSIVVS
481: GMVYYLLFFV WPFDVEEKVI VLEGMEEGDR VVRVEEAVVQ KKEAVSA