2.A.43.2.3
Vacuolar (lysosomal) cationic amino acid transporter (YOL092W) (308aas; 7 TMSs), LAAT1. Involved in cationic amino acid homeostasis (Jézégou et al. 2012). It may function as an amino acid exporter of cationic amino acids from the vacuole. The vacuole-associated Rsp5 ubiquitin ligase uses a TMS in the substrate adaptor Ssh4 to recognize membrane helices in Ypq1, which targets this lysine transporter for lysosomal degradation during lysine starvation (Zhang and Ye 2021).
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| Accession Number: | Q12010 |
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| Protein Name: | Uncharacterized membrane protein YOL092W |
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| Length: | 308 |
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| Molecular Weight: | 34873.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Vacuole membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MQLVPLELNR STLSGISGSI SISCWIIVFV PQIYENFYRK SSDGLSLLFV VLWLAGDVFN
61: LMGAVMQHLL STMIILAAYY TVADIILLGQ CLWYDNEEKP AVDPIHLSPA NPINENVLHD
121: VFNEQQPLLN SQGQPNRIDE EMAAPSSDGN AGDDNLREVN SRNLIKDIFI VSGVVFVGFI
181: SWYVTYCVNY TQPPPVEDPS LPVPELQINW MAQIFGYLSA LLYLGSRIPQ ILLNFKRKSC
241: EGISFLFFLF ACLGNTTFIF SVIVISLDWK YLIMNASWLV GSIGTLFMDF VIFSQFFIYK
301: RNKKFILN