2.A.43.2.7
Probable vacuolar (lysosomal) cationic amino acid exporter, RTC2 (Ypq3; Ybr147). Involved in amino acid homeostasis. Up-regulated by addition of ammonia or amino acids to a nitrogen-depleted medium (Jézégou et al. 2012). Resistant to fluconazole. Increased resistance to caspofungin. Suppresses CDC13-1 temperature sensitivity.
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| Accession Number: | P38279 |
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| Protein Name: | Protein RTC2 |
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| Length: | 296 |
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| Molecular Weight: | 33497.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MKLIPIILNA KNLSGMAGSI SICCWIVVFV PQIYENFRRQ SAEGLSLLFI VLWLLGDIFN
61: VMGAMMQNLL PTMIILAAYY TLADLILLIQ CMWYDKEKKS ILQEVKKNVD PVHLPPANPI
121: NETVLQDVFN EYEPLLPRIE EEDSQSYSSL ELGRTIVVKE RENFFNDFLI VSGVLIAGIL
181: SWYISYCSGL DNGIPKKKPA FEQINLPAQI LGYLSAILYL GSRIPQIVLN FKRKSCEGVS
241: FLFFLFACLG NTSFIISVLS ASWLIGSAGT LLMDFTVFIQ FFLYAKPKYE KILIDN