2.A.49.2.17
ClC-c of 893 aas and 11 TMSs. Drosophila ClC-c is a homolog of human CLC-5 and a new model for Dent Disease type 1 (Reynolds et al. 2024).
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| Accession Number: | Q9VUY1 |
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| Protein Name: | Chloride channel protein |
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| Length: | 893 |
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| Molecular Weight: | 98028.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
chloride, hydron |
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1: MEKFPLKGSR EAAAEGNSYI TAYQTVMKKS NGHTNGAGGD GDLDGTFRDH PLAQHTKLTT
61: SLTAAGTDDE DMIDITPRSS PGDVIGGGGG GGSSSGYHRE TATESDTERD FGHSGGNGGG
121: NHHNQRTMHQ HVPTHSAFGD PMDGALSFYG SSDVQDDIPG IGQYEDFHTI DWQRDIARDR
181: MRHRYIVKKR QDSLWDLIKG SIDAGSGWLC VLLVGIAAGC VAGMVDIGAS WMSDLKHGIC
241: PPAFWFNREQ CCYPAKQSVF EEGNCSTWKT WPEIFGLDRN GTGPYIVAYI WYVLWALLFA
301: SLSASLVRMF APYACGSGIP EIKTILSGFI IRGYLGKWTL LIKSVGLMLS VSAGLTLGKE
361: GPMVHIASCI GNIFSHVFPK YGRNEAKKRE ILSAAAAAGV SVAFGAPIGG VLFSLEEVSY
421: YFPLKTLWRS FFCALIAAFV LRSLTPFGNE HSVLFFVEYN KPWIFFELIP FVFLGIMGGV
481: IGTFFIKANL WWCRYRKFSK LGQYPVMEVL FVTLVTAIIC YPNPFTRMNM NELIFLLVSK
541: CSPGDVTNPL CDYKRMNITS GNSFIEVTEP GPGVYSSIWL LMLTFILKLA LTIFTFGMKV
601: PAGLFIPSLL LGAIMGRIVG IGVEQFAYSY PNIWFFTGEC ADSNLITPGL YAVVGAAAVL
661: GGVTRMTVSL VVIMFELTGG VRYIVPLMAA AMASKWVGDA LGRQGIYDAH IALNGYPFLD
721: SKEEFAHTTL AADVMQPKRN ETLNVITQDS MTVDDVENLL KETEHNGYPV VVSRENQYLV
781: GFVLRRDLNL AIGNAKRLIE GISSSSIVLF TSSQPIQNLG PQPLKLKKIL DMAPITVTDQ
841: TPMETVVDMF RKLGLRQTLV THNGRLLGVI TKKDVLRHVK QMDNEDPNTV LFN