2.A.5.4.18
Zinc transporter, ZIPT-7.1; regulates sperm activation in nematodes. In spermatids, inactive ZIPT-7.1 localizes to the intracellular membranous organelles, which contain higher levels of zinc than the cytoplasm. When sperm activation is triggered, ZIPT-7.1 activity increases, releasing zinc from internal stores. The resulting increase in cytoplasmic zinc promotes activatioin (Zhao et al. 2018).
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| Accession Number: | Q9XUC4 |
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| Protein Name: | Zinc transporter zipt-7.1 |
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| Length: | 393 |
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| Molecular Weight: | 43324.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
zinc ion |
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1: MRLQLVALLF ALVFNAFSHE HSHEHHHEGD GSEILTKVGW NDHSEELHDH HEHDHDHHDE
61: QLIRKNHTSH REIQHSRLST LKVWVFSLSA VVGISLAPCT LLFFIPAQHA NGPFLKILLA
121: FGAGGLLGDA LLHIIPHSLS PHDHSHDHHD HNHSHKEHDH SHDHSNQLRV GTFVIAGILV
181: FMMVEQLVRI IKGGHCHSHE NGHIVADEHR HLNEHDHEHS EEKKQQVEGL KDVKASAYLN
241: LVADFVHNVT DGLAIGASFS AGNTLGWITT LTVLLHELPH EVGDFAILVQ SGFSKYQAIR
301: LQAVTALGAI TGCVFSLLVS NPGSLNNDAD TSAIMPFTAG GFIYIATVSV VPELLESGDH
361: NNLSKVAKMA QSLVHVLAIC MGVGMMYIVS LVE