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2.A.52.1.4
High affinity Ni2+ uptake porter, NixA.  Transcription is regulated by NixR (Wolfram et al. 2006).  The metal selectivity and translocation mechanism in proteoliposomes of the transmembrane NiCoT transporter NixA from Helicobacter pylori have been reported (Hernandez et al. 2024).

Accession Number:Q48262
Protein Name:NixA aka HP1077
Length:331
Molecular Weight:37034.00
Species:Helicobacter pylori (Campylobacter pylori) [210]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate nickel(2+)

Cross database links:

DIP: DIP-3647N
RefSeq: NP_207868.1   
Entrez Gene ID: 899613   
Pfam: PF03824   
KEGG: hpy:HP1077   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046872 F:metal ion binding
GO:0015099 F:nickel ion transmembrane transporter activity
GO:0015675 P:nickel ion transport
GO:0055085 P:transmembrane transport

References (3)

[1] “Helicobacter pylori nickel-transport gene nixA: synthesis of catalytically active urease in Escherichia coli independent of growth conditions.”  Mobley H.L.T.et.al.   7651142
[2] “The complete genome sequence of the gastric pathogen Helicobacter pylori.”  Tomb J.-F.et.al.   9252185
[3] “Membrane topology of the NixA nickel transporter of Helicobacter pylori: two nickel transport-specific motifs within transmembrane helices II and III.”  Fulkerson J.F. Jr.et.al.   10692379

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKLWFPYFLA IVFLHALGLA LLFMANNASF YAAASMAYML GAKHAFDADH IACIDNTIRK 
61:	LTQQGKNAYG VGFYFSMGHS SVVILMTIIS AFAIAWAKEH TPMLEEIGGV VGTLVSGLFL 
121:	LIIGLLNAII LLDLLKIFKK SHSNESLSQQ QNEEIERLLT SRGLLNRFFK PLFNFVSKSW 
181:	HIYPIGFLFG LGFDTASEIA LLALSSSAIK VSMVGMLSLP ILFAAGMSLF DTLDGAFMLK 
241:	AYDWAFKTPL RKIYYNISIT ALSVFIALFI GLIELFQVVS EKLHLKFENR LLRALQSLEF 
301:	TDLGYYLVGL FVIAFLGSFF LWKIKFSKLE S