2.A.52.1.7 NicT is a heavy metal transporter of 372 aas with 8 TMSs in a 4 + 4 TMS arrangement suggesting of a 4 TMS repeat unit. Actually it looks like a 2 + 2 + 2 + 2 arrangement. It is a NiCoT family transporter of Mycobacterium tuberculosis (Rv2856/NicT). It also behaves as a drug efflux pump that facilitates cross-resistance to antibiotics (Adhikary et al. 2022).
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Accession Number: | O05804 |
Protein Name: | HoxN/HupN/NixA family nickel transporter |
Length: | 372 |
Molecular Weight: | 40534.00 |
Species: | Mycobacterium tuberculosis [1773] |
Number of TMSs: | 8 |
Substrate |
nickel(2+), antimicrobial agent, drug |
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1: MASSQLDRQR SRSAKMNRAL TAAEWWRLGL MFAVIVALHL VGWLTVTLLV EPARLSLGGK
61: AFGIGVGLTA YTLGLRHAFD ADHIAAIDNT TRKLMSDGHR PLAVGFFFSL GHSTVVFGLA
121: VMLVTGLKAI VGPVENDSST LHHYTGLIGT SISGAFLYLI GILNVIVLVG IVRVFAHLRR
181: GDYDEAELEQ QLDNRGLLIR FLGRFTKSLT KSWHMYPVGF LFGLGFDTAT EIALLVLAGT
241: SAAAGLPWYA ILCLPVLFAA GMCLLDTIDG SFMNFAYGWA FSSPVRKIYY NITVTGLSVA
301: VALLIGSVEL LGLIANQLGW QGPFWDWLGG LDLNTVGFVV VAMFALTWAI ALLVWHYGRV
361: EERWTPAPDR TT