2.A.54.1.8
Sideroflexin 2, SFXN2, TMEM241 or SLC56A2, of 322 aas and 5 or 6 TMSs in a 1 or 2 + 2 + 2 TMS arrangement.  SFXN2 is involved in mitochondrial iron metabolism and is localized to the mitochondrial inner membrane (Mon et al. 2019). SFXN2-knockout (KO) cells have an increased mitochondrial iron content and decreases in the heme content and heme-dependent enzyme activities. By contrast, the activities of iron-sulfur cluster-dependent enzymes were unchanged. Abnormal iron metabolism impaired mitochondrial respiration in SFXN2-KO cells and accelerated iron-mediated death (Mon et al. 2019). It may exert its effects by alterning heme biosynthesis.