2.A.55.2.9
NRAMP1 (SLC11a1) of 533 aas and 11 TMSs. Regulates iron homeostasis and bacterial infection; present in phagosomes and macropinosomes (Peracino et al. 2013). Transports metal cations out of the phagolysosome, thereby depleting iron. Nramp1 overexpression
protects cells from L. pneumophila infection (Peracino et al. 2006). Nramp1 and NrampB (Nramp2) are in membranes of macropinosomes and in phagosomes or the contractile vacuole network, respectively (Peracino et al. 2022).
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| Accession Number: | Q869V1 |
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| Protein Name: | Metal transporter nramp1 homolog |
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| Length: | 533 |
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| Molecular Weight: | 60034.00 |
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| Species: | Dictyostelium discoideum (Slime mold) [44689] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
iron(2+) |
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1: MTPRIESEES APLVNKNNNN NNDNNNNNNV DEENPLIIES GIPIEDLEQK NKPYLIKVPN
61: IDKPDSKWIN FKTLWAFTGP GFLMSIAYLD PGNLESDIQA GAMAGYQLLW VLFWSTVIGF
121: WLQMLASRLG VVTGKHLAEH CREQYPKTPR LLLWLMTELA IIGSDIQEVI GTAIALQILS
181: NGHIPLWAGV LFTAADTFTF LFLEKYGIRK LEAFFCSLIA IMAISFGVEY IISKPDQIEV
241: VKGVFIPLCS QNNISQAVGI LGAVVMPHNI YLHSALVQSR EIDRKSETQV KIANKYNRLE
301: SAFALIISFI INLLLVSVFA KGFYGETTEI GLSSAADFLM DKYGKVAKYI WAIGLFSAGQ
361: CSTMTGTYSG QFVMEGFLKL KIAPWKRLLI TRCTAIVPAM VVAILSTSHL DSLDQWLNIL
421: QSIQLPFAVV PVLLFTSSEK IMGSKFKNHW LNNQFVRFLS LLIIAINIYL IITFSMQISE
481: SAWMISIVSI SFFFYFIFIV YLSMGQENFN SMTKKIKNLF NNNSNQTYNN INY