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2.A.57.2.1
Concentrative nucleoside (adenosine, uridine, cytosine, tubercidin):H+ symporter, NT1.1 (The Leishmania major orthologue, NT1.1 (Q4QF58), also transports tubercidin) (Stein et al., 2003). TMS 5 is an amphipathic helix that forms part of the nucleoside translocation pathway (Valdés et al. 2004). The intracellular and extracellular gates have been defined by modeling FucP (Valdés et al. 2012; Valdés et al. 2014).

Accession Number:O76343
Protein Name:NT1.1
Length:491
Molecular Weight:53962.00
Species:Leishmania donovani [5661]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Adenosine, Uridine, Cytosine, Tubercidin, H+

Cross database links:

Pfam: PF01733   

Gene Ontology

GO:0016020 C:membrane
GO:0005337 F:nucleoside transmembrane transporter activity
GO:0006810 P:transport

References (1)

[1] “Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant.”  Vasudevan G.et.al.   9707568

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDTAPDHREP QEQGESRKWY EMTASEFYVY VVAFMCGVSM MMPVNAVFSA PAYIMTYYRY 
61:	AMQDPEAVPL YTNFWNNVMT YYNLIGIVTS LIMEPLTLLS WFRRIPMKVR LLGGLVILIV 
121:	EIIVLMVVPA RGTSEAGAVA TICCTGFIGG FGKSIFESTT YGMFGAFPSS FTSTMMGGVG 
181:	MSGVLTSLLQ IIVKAALPDS YEGVKKQSKI YYGLDVGIQG MTFVALILLR FNSFAQNYFG 
241:	DLGAVKSKVD AGKLSAEALC HTDEHPTHDK EGRNSSSGKE VPALGEVQTA AAKSEGPDAV 
301:	EESSWPHEVE GPTSNEILVA TAIFSTLRRV KWMFVACAFN FLITLFLFPG IAVGMFPDSK 
361:	WFSTIAVFIF NVFDVLGRFS PSLKLMWPRS YKQRWIIVAA SFARVIFVPL LLLHSYHYIP 
421:	GEAYGYVMEV IFGFSNGYVG SMALVLGPQS KGIDNDGKRF VAGTLMGISI LVGGTIGTVL 
481:	SIMTQTIRAT Y