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2.A.6.1.3
Silver ion (Ag+)-specific efflux pump of the RND family. Silver ion resistance mechanisms of E. coli, this article reviews the complex regulatory network and various physiological mechanisms of silver ion tolerance in E. coli, including the regulation of outer membrane porins, energy metabolism modulation, the role of efflux systems, motility regulation, and silver ion reduction (Wu et al. 2025).

Accession Number:Q9ZHC9
Protein Name:SilA
Length:1048
Molecular Weight:114604.00
Species:Salmonella typhimurium [90371]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate silver(1+)

Cross database links:

Pfam: PF00873   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0008324 F:cation transmembrane transporter activity
GO:0006812 P:cation transport

References (1)

[1] “Molecular basis for resistance to silver cations in Salmonella.”  Gupta A.et.al.   9930866

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIEWIIRRSV ANRFLVMMGA LFLSIWGTWT IINTPVDALP DLSDVQVIIK TSYPGQAPQI 
61:	VENQVTYPLT TTMLSVPGAK TVRGFSQFGD SYVYVIFEDG TDLYWARSRV LEYLNQVQGK 
121:	LPAGVSSEIG PDATGVGWIF EYALVDRSGK HDLSELRSLQ DWFLKFELKT IPNVAEVASV 
181:	GGVVKQYQIQ VNPVKLSQYG ISLPEVKQAL ESSNQEAGGS SVEIAEAEYM VRASGYLQSI 
241:	DDFNNIVLKT GENGVPVYLR DVARVQTGPE MRRGIAELNG QGEVAGGVVI LRSGKNARDV 
301:	ITAVRDKLET LKASLPEGVE IVTTYDRSQL IDRAIDNLSS KLLEEFFVVA IVCALFLWHV 
361:	RSALVAIISL PLGLCIAFIV MHFQGLNANI MSLGGIAIAV GAMVDAAIVM IENAHKRLEE 
421:	WDHRHPGEQI DNVTRWKVIT DASVEVGPAL FISLLIITLS FIPIFTLEGQ EGRLFGPLAF 
481:	TKTYSMAGAA ALAIIVIPIL MGFWIRGKIP AETSNPLNRV LIKAYHPLLL RVLHWPKTTL 
541:	LVAALSIFTV VWPLSQVGGE FLPKINEGDL LYMPSTLPGV SPAEAAALLQ TTDKLIKSVP 
601:	EVASVFGKTG KAETATDSAP LEMVETTIQL KPEDQWRPGM TIDKIIDELD RTVRLPGLAN 
661:	LWVPPIRNRI DMLSTGIKSP IGIKVSGTVL SDIDATAQSI EAVAKTVPGV VSVLAERLEG 
721:	GRYIDIDINR EKASRYGMTV GDVQLFVSSA IGGAMVGETV EGVARYPINI RYPQDYRNSP 
781:	QALKQMPILT PMKQQITLGD VADINVVSGP TMLKTENARP ASWIYVDARG RDMVSVVNDI 
841:	KTAISEKVKL RPGTSVAFSG QFELLEHANK KLKLMVPMTV MIIFILLYLA FRRVDEALLI 
901:	LMSLPFALVG GIWFLYWQGF HMSVATGTGF IALAGVAAEF GVVMLMYLRH AIEAHPELSR 
961:	KETFTPEGLD EALYHGAVLR VRPKAMTVAV IIAGLLPILW GTGAGSEVMS RIAAPMIGGM 
1021:	ITAPLLSLFI IPAAYKLIWL RRHKKSVS