2.A.6.2.48
Multidrug resistance (MDR) pump, AcrD, AcrF, Env. Catalyzes efflux of various hydrophilic and amphipathic drugs including clotrimazole and luteolin, but not aminoglycosides. Induction of acrD expression occurs in infected apple tissue but not in pear tissues. Regulated by the two component BaeSR sensor kinase/response regulator (Pletzer and Weingart 2014).
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| Accession Number: | E3DBE3 |
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| Protein Name: | Acriflavine resistance protein B |
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| Length: | 1037 |
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| Molecular Weight: | 112689.00 |
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| Species: | Erwinia sp. (strain Ejp617) [215689] |
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| Number of TMSs: | 12 |
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| Substrate |
luteolin, clotrimazole |
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1: MANFFIDRPI FAWVLAILLC LTGGLAIVSL PIEQYPDLAP PNVRITANYP GASAETLENT
61: VTQVIEQNMT GLDNLMYMSS QSSHTGQATV TLTFEAGTNP DEARQQVQNQ LQTALRKLPQ
121: DVQAQGVNVN KTGDTNILMV AFVSTDGSMD KQDIADYVAS HLQDPLSRIN GVGQVDAYGS
181: QYAMRIWLDP NKLINYALTT TEVVDAIKSQ NSQVAVGQLG GLPSVDRQAL NATINAQSLL
241: QTPQQFRAIT LKVNADGSVV TLGQVAQVAL GAEKYDYLSR YNGMAASGLG IKLASGANEL
301: QTDKLVRARL DELSRFFPHG LQAEIAFETS PFVKASIEDV VKTLFEAVLL VFLVMYLFLQ
361: NFRATLIPTI AVPVVLFGTF GVLYAFGYSI NTLTMFAMVL AIGLLVDDAI VVVENVERIM
421: TEEGLSPRDA TRKSMGQIQG ALVGIALVLS AVFVPMAFFG GTTGAIYRQF SVTIVSAMVL
481: SVLVAMILTP ALCCTLLKPL AMGHHHGQRG FFGWFNRTFN HNAERYKRGV GRMLVKGGRW
541: LVVYLALIAV MALLFMRLPT SFLPLEDRGL FTTQVQLPPG STLQQTMTVV EKVEHYYLTH
601: EQDNVQSVFA TVGAGPGGNG QNVARLFVRL KDWQNRLGSD NTSFAIIDRA TKAFSRINEA
661: KVVASSPSAI TGLGNSAGFD MELQDNAGLG HRALMNARNT LLEMAQKNPS LTRVRHNGLD
721: DSPQLRIDID QRKAQTLGVS LHDINATLQT GWGSTYVNDF LDRGRVKKVY VQADAPFRML
781: PDDISKWYVR NASGGMVPFT AFARSHWENG SPRLERYNGY PALEIVGESA AGVSNGAAMD
841: MMEKLVSQLP NGIGLQWTGA SLQERMTGAQ APALYALSLL VVFLCLAALY ESWSIPFSVM
901: LVVPLGVLGA LIATWLRGLE NDVYFQVGLL TVVGLSAKNA ILIVEFANEI NSRGSELMAA
961: TLEAARQRLR PILMTSLAFI FGVLPMAISQ GAGSSSQHAV GTGVLGGMIS ATVLAIFFVP
1021: LFFVLVRRRF PLKDKPQ