2.A.6.5.10
Multidrug resistance protein, CmpL1, of 772 aas and 12 TMSs. Mutants are hypersusceptible to multiple antibiotics, have growth deficiencies
in minimal medium and accumulate intracellular trehalose
monocorynomycolates, free corynomycolates, and a previously
uncharacterized corynomycolate-containing lipid. It is inferred that this transporter exports one or more of these lipids. Evidence for a pmf-dependent mechanism was obtained (Yang et al. 2014).
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| Accession Number: | Q8NLS1 |
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| Protein Name: | Predicted drug exporters of the RND superfamily |
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| Length: | 772 |
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| Molecular Weight: | 83056.00 |
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| Species: | Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) [196627] |
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| Number of TMSs: | 12 |
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| Substrate |
drug |
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1: MFSKWGHFAY RFRRIVPLVV IAAILALFVI FGTKLGDRMS QEGWDDPGSS STAAARIELE
61: TFGRDNDGDV VLLFTAPEGT SFDDAEVFSS ISGYLDGLIE NNPDEVSHIN SYFDTRNQNL
121: LSKDGTQTFA ALGLKGDGEQ TLKDFREIED QLHPDNLAGG VTTEVAGATA VADALDEGMA
181: GDISRAEVFA LPFVAILLLI VFGSVVAAAM PLIVGILSIL GSLGILAILA GFFQVNVFAQ
241: SVVTLLGLGL AIDYGLFMVS RFREEMDKGT PVEQAVATTT ATAGKTVVFS AAMVAVALSG
301: LFVFPQAFLK SVAFGAISAV GLAALMSVTV LPSLFSMLGK NIDKWSLRRT ARTARRLEDT
361: IWYRVPAWAM RHAKAVTVGV VLLLLALTVP LTGVKFGGIN ETYLPPANDT RVAQERFDEA
421: FPAFRTEPVK LVVTGADNNQ LIDIYVQANE VEGLTDRFTA GATTDDGTTV LSTGIQDRSL
481: NEQVVEQLRA ISVPEGVEVQ IGGTPAMEIE SIEALFEKLL WMALYIVLAT FILMALVFGS
541: VILPAKAIIM TILGMGATLG ILTLMFVDGV GASALNFSPG PLMSPVLVLI MAIIYGLSTD
601: YEVFLVSRMV EARDKGESTD DAIRYGTAHT GSIITAAALI MIVVCGAFGF SEIVMMKYIA
661: FGMIAALILD ATIIRMLLVP AVMHLLRDDN WWAPGFVKKA YTVMGHGSEV EEAPRPTTRR
721: LNDDEEVTVH EAVVAGDTVA SRGGLSTQEN RDLVSFVELK ARLEKRRLED LD