2.A.6.5.13
Lipid (acyl and diacyl trehalose) exporter of 1002 aas and 12 TMSs, MmpL10 (Bailo et al. 2015). A 12 TMS topology has been determined (Belardinelli and Jackson 2017).
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| Accession Number: | P9WJU1 |
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| Protein Name: | Acyltrehalose exporter MmpL10 |
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| Length: | 1002 |
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| Molecular Weight: | 106415.00 |
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| Species: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [83332] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
acyl alpha,alpha-trehalose |
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1: MVGCWVALAL VLPMAVPSLA EMAQRHPVAV LPADAPSSVA VRQMAEAFHE SGSENILVVL
61: LTDEKGLGAA DENVYHTLVD RLRNDAKDVV MLQDFLTTPP LREVLGSKDG KAWILPIGLA
121: GDLGTPKSYH AYTDVERIVK RTVAGTTLTA NVTGPAATVA DLTDAGARDR ASIELAIAVM
181: LLVILMVIYR NPVTMLLPLV TIGASLMTAQ ALVAGVSLVG GLAVSNQAIV LLSAMIAGAG
241: TDYAVFLISR YHEYVRLGEH PERAVQRAMM SVGKVIAASA ATVGITFLGM RFAKLGVFST
301: VGPALAIGIA VSFLAAVTLL PAILVLASPR GWVAPRGERM ATFWRRAGTR IVRRPKAYLG
361: ASLIGLVALA SCASLAHFNY DDRKQLPPSD PSSVGYAAME HHFSVNQTIP EYLIIHSAHD
421: LRTPRGLADL EQLAQRVSQI PGVAMVRGVT RPNGETLEQA RATYQAGQVG NRLGGASRMI
481: DERTGDLNRL ASGANLLADN LGDVRGQVSR AVAGVRSLVD ALAYIQNQFG GNKTFNEIDN
541: AARLVSNIHA LGDALQVNFD GIANSFDWLD SVVAALDTSP VCDSNPMCGN ARVQFHKLQT
601: ARDNGTLDKV VGLARQLQST RSPQTVSAVV NDLGRSLNSV VRSLKSLGLD NPDAARARLI
661: SMQNGANDLA SAGRQVADGV QMLVDQTKNM GIGLNQASAF LMAMGNDASQ PSMAGFNVPP
721: QVLKSEEFKK VAQAFISPDG HTVRYFIQTD LNPFSTAAMD QVNTIIDTAK GAQPNTSLAD
781: ASISMSGYPV MLRDIRDYYE RDMRLIVAVT VVVVILILMA LLRAIVAPLY LVGSVVISYM
841: SAIGLGVVVF QVFLGQELHW SVPGLAFVVL VAVGADYNML LASRLRDESA LGVRSSVIRT
901: VRCTGGVITA AGLIFAASMS GLLFSSIGTV VQGGFIIGVG ILIDTFVVRT ITVPAMATLL
961: GRASWWPGHP WQRCAPEEGQ MSARMSARTK TVFQAVADGS KR