2.A.6.5.7
Siderophore export transporter, MmpL4 (Wells et al. 2013). Functions with MmpS4 (TC#8.A.35.1.1) which is essential for transport activity. MmpL4/MmpS4 and MmpL5/MmpS5 (TC# 2.A.6.5.8 and TC# 8.A.35.1.2, respectively) are two siderophore exporters that overlap in function (Wells et al. 2013). The M. abscessus, subspecies bolletii orthologue (TC# 2.A.6.5.12), of 959 aas, is 65% identical to M. tuberculosis MmpL4 and affects the rough vs smooth phenotype of the cell envelope (Bernut et al. 2016).
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| Accession Number: | O53735 |
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| Protein Name: | Putative membrane protein mmpL4 |
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| Length: | 967 |
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| Molecular Weight: | 105234.00 |
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| Species: | Mycobacterium tuberculosis [1773] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
siderophore |
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1: MSTKFANDSN TNARPEKPFI ARMIHAFAVP IILGWLAVCV VVTVFVPSLE AVGQERSVSL
61: SPKDAPSFEA MGRIGMVFKE GDSDSFAMVI IEGNQPLGDA AHKYYDGLVA QLRADKKHVQ
121: SVQDLWGDPL TAAGVQSNDG KAAYVQLSLA GNQGTPLANE SVEAVRSIVE STPAPPGIKA
181: YVTGPSALAA DMHHSGDRSM ARITMVTVAV IFIMLLLVYR SIITVVLLLI TVGVELTAAR
241: GVVAVLGHSG AIGLTTFAVS LLTSLAIAAG TDYGIFIIGR YQEARQAGED KEAAYYTMYR
301: GTAHVILGSG LTIAGATFCL SFARMPYFQT LGIPCAVGML VAVAVALTLG PAVLHVGSRF
361: GLFDPKRLLK VRGWRRVGTV VVRWPLPVLV ATCAIALVGL LALPGYKTSY NDRDYLPDFI
421: PANQGYAAAD RHFSQARMKP EILMIESDHD MRNPADFLVL DKLAKGIFRV PGISRVQAIT
481: RPEGTTMDHT SIPFQISMQN AGQLQTIKYQ RDRANDMLKQ ADEMATTIAV LTRMHSLMAE
541: MASTTHRMVG DTEEMKEITE ELRDHVADFD DFWRPIRSYF YWEKHCYGIP ICWSFRSIFD
601: ALDGIDKLSE QIGVLLGDLR EMDRLMPQMV AQIPPQIEAM ENMRTMILTM HSTMTGIFDQ
661: MLEMSDNATA MGKAFDAAKN DDSFYLPPEV FKNKDFQRAM KSFLSSDGHA ARFIILHRGD
721: PQSPEGIKSI DAIRTAAEES LKGTPLEDAK IYLAGTAAVF HDISEGAQWD LLIAAISSLC
781: LIFIIMLIIT RAFIAAAVIV GTVALSLGAS FGLSVLLWQH ILAIHLHWLV LAMSVIVLLA
841: VGSDYNLLLV SRFKQEIGAG LKTGIIRSMG GTGKVVTNAG LVFAVTMASM AVSDLRVIGQ
901: VGTTIGLGLL FDTLIVRSFM TPSIAALLGR WFWWPLRVRS RPARTPTVPS ETQPAGRPLA
961: MSSDRLG