2.A.6.7.8
Hopanoid biosynthesis associated RND transporter like protein, HpnN of 877 aas and 12 TMSs. Hopanoid biosynthesis is one of the major mechanisms involved in multiple antimicrobial resistance of Bcc pathogens. The hpnN gene of B. multivorans encodes an integral membrane protein of the HpnN family of transporters, which is responsible for shuttling hopanoids to
the outer membrane. Kumar et al. 2017 reported crystal structures of B. multivorans HpnN,
revealing a dimeric molecule with an overall butterfly shape. Each
subunit of the transporter contains 12 transmembrane helices and two
periplasmic loops that suggest a plausible pathway for substrate
transport. Further analyses indicated that HpnN is capable of shuttling hopanoid virulence factors from the outer leaflet of the inner membrane to the periplasm (Kumar et al. 2017).
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| Accession Number: | J5C9U3 |
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| Protein Name: | Hopanoid biosynthesis associated RND transporter like protein HpnN |
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| Length: | 877 |
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| Molecular Weight: | 92736.00 |
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| Species: | Burkholderia multivorans CF2 [985078] |
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| Number of TMSs: | 13 |
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| Substrate |
hopanoid |
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1: MVTSLIVRLV AWSVRRPVWV VVLSLLIAAF SGVYVARHFK INTDISKLVD AEPQWAALSQ
61: AVDRAFPQRN GTILAVVEAP APEFATAAAH ALTESLQKQA AAGRIGPVAE PGGGPFFEHN
121: GLLFLSPQQV ADTTSQLASA RPLVNELAKN PSLTGLATTL STTLGQPLLT GQVKLPSMAK
181: LLSRSAATVD DVLAGKPAAF SWRALVDNDA ARQPARAFVT VQPVVNYGAL KAGAQTSDVI
241: RETARALDLE KRYGAVVRLT GEQPLADDEF SSVEDGAALN GVVTLLVVFV ILWLALRSKR
301: MIASVLVTLF VGLVVTAALG LAMVGSLNMI SVAFMVLFVG LGVDFSIQYG VKYREERFRD
361: ARIDHALIGA AHSMGMPLAL ATTAVAASFF SFIPTAYRGV SELGLIAGVG MFVALLTTLT
421: LLPALLRLFA PPGESKTPGF PWLAPVDDYL DRHRKPILIG TLAVVIGALP LLAFLHFDFN
481: PLHLKDPHSE SMSTLLALKD SPEAAVNDVT LLAPSLADAD AAAKRLDALP EVGRTTTLST
541: FIPADQPEKR AAIATAASTL LPALTQPPAP PATDAQRVAA LKRASDLLGY AAEDHPGPGA
601: AAAQHLSQSL AKLAAADSAT RDRAERAFAD TLRIALNQLA ALLQPQEITR DTLPPPLVRD
661: WVAPDGKALV QISPKVPKGV DPNDDTMLRH FATAVKAAEP GAIGGPISIL HSANTIISAF
721: LHAALWSIIS ITILLWITLR RFGDVLRTLV PLLVSGIVTL EMCVVLGMSL NFANIIALPL
781: MLGVGVAFKV YFVMAWRAGQ TGLLHSSLTH AVLFSAATTA TAFGSLWLSH HPGTSSMGKL
841: LALALTCTLI GAVVFQPVLM GKPRVKRAKN QSQGINE