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| Accession Number: | Q6ZQN7 |
| Protein Name: | Solute carrier organic anion transporter family member 4C1 |
| Length: | 724 |
| Molecular Weight: | 78948.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Basolateral cell membrane1 / Multi-pass membrane protein2 |
| Substrate | 3,3',5-triiodo-L-thyronine, methotrexate, 3',5'-cyclic AMP, ouabain, cardenolide glycoside, thyroxine, digoxin |
Cross database links:
| RefSeq: | NP_851322.3 |
|---|---|
| Entrez Gene ID: | 353189 |
| Pfam: | PF07648 PF03137 |
| OMIM: |
609013 gene |
| KEGG: | hsa:353189 hsa:353189 |
Gene Ontology
GO:0016323
C:basolateral plasma membrane
GO:0016021
C:integral to membrane
GO:0005215
F:transporter activity
GO:0030154
P:cell differentiation
GO:0006811
P:ion transport
GO:0007275
P:multicellular organismal development
GO:0007283
P:spermatogenesis
GO:0005886
C:plasma membrane
GO:0043252
P:sodium-independent organic anion transport
GO:0055085
P:transmembrane transport
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References (6)[1] “Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.” Mikkaichi T.et.al. 14993604 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein.” Chu X.-Y.et.al. 17314201 [4] “Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.” Mikkaichi T.et.al. 14993604 [5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [6] “Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein.” Chu X.-Y.et.al. 17314201
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MKSAKGIENL AFVPSSPDIL RRLSASPSQI EVSALSSDPQ RENSQPQELQ KPQEPQKSPE 61: PSLPSAPPNV SEEKLRSLSL SEFEEGSYGW RNFHPQCLQR CNTPGGFLLH YCLLAVTQGI 121: VVNGLVNISI STVEKRYEMK SSLTGLISSS YDISFCLLSL FVSFFGERGH KPRWLAFAAF 181: MIGLGALVFS LPQFFSGEYK LGSLFEDTCV TTRNSTSCTS STSSLSNYLY VFILGQLLLG 241: AGGTPLYTLG TAFLDDSVPT HKSSLYIGTG YAMSILGPAI GYVLGGQLLT IYIDVAMGES 301: TDVTEDDPRW LGAWWIGFLL SWIFAWSLII PFSCFPKHLP GTAEIQAGKT SQAHQSNSNA 361: DVKFGKSIKD FPAALKNLMK NAVFMCLVLS TSSEALITTG FATFLPKFIE NQFGLTSSFA 421: ATLGGAVLIP GAALGQILGG FLVSKFRMTC KNTMKFALFT SGVALTLSFV FMYAKCENEP 481: FAGVSESYNG TGELGNLIAP CNANCNCSRS YYYPVCGDGV QYFSPCFAGC SNPVAHRKPK 541: VYYNCSCIER KTEITSTAET FGFEAKAGKC ETHCAKLPIF LCIFFIVIIF TFMAGTPITV 601: SILRCVNHRQ RSLALGIQFM VLRLLGTIPG PIIFGFTIDS TCILWDINDC GIKGACWIYD 661: NIKMAHMLVA ISVTCKVITM FFNGFAIFLY KPPPSATDVS FHKENAVVTN VLAEQDLNKI 721: VKEG