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2.A.60.1.19
Solute carrier organic anion transporter family member, OATP2A1; SLCO2A1;  (Prostaglandin uptake transporter, PGT) (Solute carrier family 21 member 1 or 2). Transports prostaglandins E2, F2α and D2 as well as throboxanes (TxB2), inorganic and organic anions, and it plays a role in F4-mediated neonatal diarrhoea. (Schuster 2002; Ohkura et al. 2014). A mutation in the PGT gene  induces chronic enteropathy (Jimbo et al. 2020). It is electrogenic and uptake can be driven by the efflux of lactate.   The system has been reviewed (Nakanishi et al. 2021). Recessive inheritance of SLCO2A1 mutations is associated with two refractory diseases, primary hypertrophic osteoarthropathy (PHO) and chronic enteropathy associated with SLCO2A1 (CEAS). SLCO2A1 is also a key component of the Maxi-Cl- channel, which regulates fluxes of inorganic and organic anions, including ATP. The bimodal function of SLCO2A1 as a transporter and an ion channel have been reviewed (Nakanishi et al. 2021). Homozygous missense variants in the Solute Carrier Organic Anion Transporter 2A1 ( SLCO2A1) gene underlies isolated nail clubbing (Umair et al. 2023).

Accession Number:Q92959
Protein Name:Solute carrier organic anion transporter family member 2A1
Length:643
Molecular Weight:70044.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate inorganic anion, chloride, organic anion, ATP, prostaglandin E2, lactate, thromboxane

Cross database links:

Entrez Gene ID: 6578   
Pfam: PF07648    PF03137   
KEGG: hsa:6578   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005319 F:lipid transporter activity
GO:0015132 F:prostaglandin transmembrane transporter activity
GO:0043252 P:sodium-independent organic anion transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT).”  Lu R.et.al.   8787677
[2] “Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization.”  Lu R.et.al.   9618293
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy.”  Zhang Z.et.al.   22197487
Structure:
3MRR     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGLLPKLGAS QGSDTSTSRA GRCARSVFGN IKVFVLCQGL LQLCQLLYSA YFKSSLTTIE 
61:	KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVHRPRL IGIGGLFLAA GAFILTLPHF 
121:	LSEPYQYTLA STGNNSRLQA ELCQKHWQDL PPSKCHSTTQ NPQKETSSMW GLMVVAQLLA 
181:	GIGTVPIQPF GISYVDDFSE PSNSPLYISI LFAISVFGPA FGYLLGSVML QIFVDYGRVN 
241:	TAAVNLVPGD PRWIGAWWLG LLISSALLVL TSFPFFFFPR AMPIGAKRAP ATADEARKLE 
301:	EAKSRGSLVD FIKRFPCIFL RLLMNSLFVL VVLAQCTFSS VIAGLSTFLN KFLEKQYGTS 
361:	AAYANFLIGA VNLPAAALGM LFGGILMKRF VFSLQAIPRI ATTIITISMI LCVPLFFMGC 
421:	STPTVAEVYP PSTSSSIHPQ SPACRRDCSC PDSIFHPVCG DNGIEYLSPC HAGCSNINMS 
481:	SATSKQLIYL NCSCVTGGSA SAKTGSCPVP CAHFLLPAIF LISFVSLIAC ISHNPLYMMV 
541:	LRVVNQEEKS FAIGVQFLLM RLLAWLPSPA LYGLTIDHSC IRWNSLCLGR RGACAYYDND 
601:	ALRDRYLGLQ MGYKALGMLL LCFISWRVKK NKEYNVQKAA GLI