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|---|---|
| Accession Number: | Q96BD0 |
| Protein Name: | SLC21A12 aka OATPE aka OATP1 |
| Length: | 722 |
| Molecular Weight: | 77193.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | bilirubin, icosanoid, bile acid, thyroid hormone, drug |
Cross database links:
| RefSeq: | NP_057438.3 |
|---|---|
| Entrez Gene ID: | 28231 |
| Pfam: | PF07648 PF03137 |
| OMIM: |
612436 gene |
| KEGG: | hsa:28231 hsa:28231 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005215
F:transporter activity
GO:0006811
P:ion transport
GO:0005886
C:plasma membrane
GO:0015349
F:thyroid hormone transmembrane transporter activity
GO:0043252
P:sodium-independent organic anion transport
GO:0042403
P:thyroid hormone metabolic process
GO:0055085
P:transmembrane transport
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References (18)[1] “Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.” Tamai I.et.al. 10873595 [2] “Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner.” Fujiwara K.et.al. 11316767 [3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [4] “The DNA sequence and comparative analysis of human chromosome 20.” Deloukas P.et.al. 11780052 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Large-scale characterization of HeLa cell nuclear phosphoproteins.” Beausoleil S.A.et.al. 15302935 [7] “Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.” Cantin G.T.et.al. 18220336 [8] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.” Daub H.et.al. 18691976 [9] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [10] “Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.” Tamai I.et.al. 10873595 [11] “Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner.” Fujiwara K.et.al. 11316767 [12] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [13] “The DNA sequence and comparative analysis of human chromosome 20.” Deloukas P.et.al. 11780052 [14] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MPLHQLGDKP LTFPSPNSAM ENGLDHTPPS RRASPGTPLS PGSLRSAAHS PLDTSKQPLC 61: QLWAEKHGAR GTHEVRYVSA GQSVACGWWA FAPPCLQVLN TPKGILFFLC AAAFLQGMTV 121: NGFINTVITS LERRYDLHSY QSGLIASSYD IAACLCLTFV SYFGGSGHKP RWLGWGVLLM 181: GTGSLVFALP HFTAGRYEVE LDAGVRTCPA NPGAVCADST SGLSRYQLVF MLGQFLHGVG 241: ATPLYTLGVT YLDENVKSSC SPVYIAIFYT AAILGPAAGY LIGGALLNIY TEMGRRTELT 301: TESPLWVGAW WVGFLGSGAA AFFTAVPILG YPRQLPGSQR YAVMRAAEMH QLKDSSRGEA 361: SNPDFGKTIR DLPLSIWLLL KNPTFILLCL AGATEATLIT GMSTFSPKFL ESQFSLSASE 421: AATLFGYLVV PAGGGGTFLG GFFVNKLRLR GSAVIKFCLF CTVVSLLGIL VFSLHCPSVP 481: MAGVTASYGG SLLPEGHLNL TAPCNAACSC QPEHYSPVCG SDGLMYFSLC HAGCPAATET 541: NVDGQKVYRD CSCIPQNLSS GFGHATAGKC TSTCQRKPLL LVFIFVVIFF TFLSSIPALT 601: ATLRCVRDPQ RSFALGIQWI VVRILGGIPG PIAFGWVIDK ACLLWQDQCG QQGSCLVYQN 661: SAMSRYILIM GLLYKVLGVL FFAIACFLYK PLSESSDGLE TCLPSQSSAP DSATDSQLQS 721: SV