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2.A.66.1.1
Drug:Na+ antiporter (norfloxacin, ethidium, kanamycin, ciprofloxin, streptomycin efflux pump), NorM. Transport is dependent on Na+, and several essential residiues have been identified. Specifically, Asp32, Glu251, and Asp367 are involved in the Na+-dependent drug transport process. (Otsuka et al. 2005).

Accession Number:O82855
Protein Name:NorM aka VP1479
Length:456
Molecular Weight:49280.00
Species:Vibrio parahaemolyticus [670]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate sodium(1+), norfloxacin, streptomycin, kanamycin, ethidium

Cross database links:

RefSeq: NP_797858.1   
Entrez Gene ID: 1188986   
Pfam: PF01554   
BioCyc: VPAR223926:VP1479-MONOMER   
KEGG: vpa:VP1479   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015238 F:drug transmembrane transporter activity
GO:0006855 P:drug transmembrane transport
GO:0046677 P:response to antibiotic
GO:0006814 P:sodium ion transport

References (4)

[1] “NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli.”  Morita Y.et.al.   9661020
[2] “Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae.”  Makino K.et.al.   12620739
[3] “The multidrug efflux protein NorM is a prototype of a new family of transporters.”  Brown M.H.et.al.   9987140
[4] “NorM of Vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump.”  Morita Y.et.al.   11073914

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MHRYKEEASS LIKLATPVLI ASVAQTGMGF VDTVMAGGVS ATDMAAVSVA SSIWLPSILF 
61:	GIGLLMALVP VVAQLNGSAR REKIPFEIQQ GVVLALLISI PIIGVLLQTQ FILQLMDVEA 
121:	VMAGKTVGYI HAVIFAVPAF LLFQTLRSFT DGMSLTKPAM VIGFIGLLLN IPLNWIFVYG 
181:	KFGAPELGGV GCGVATTIVY WVMFALLLAY VMTSSRLKSI NVFGEYHKPQ WKAQVRLFKL 
241:	GFPVAAALFF EVTLFAVVAL LVSPLGPIIV AAHQVAINFS SLVFMLPMSV GAAVSIRVGH 
301:	RLGEENVDGA RVASRVGIMV GLALATITAI ITVLSRELIA ELYTNNPEVI SLAMQLLLFA 
361:	AVYQCTDAVQ VIAAGALRGY KDMRAIFNRT FIAYWILGLP TGYILGRTDW IVEPMGAQGF 
421:	WLGFIIGLTA AALMLGVRLR WMHRQEPDVQ LNFSLQ