2.A.71.1.6 Folate/biopterin/methotrexate transporter, BT1, of 1057 aas and 14 TMSs in the N-terminal half of the protein (residues 1 - 500) with an equally long C-terminal hydrophilic domain. Uptake of folate across the parasite plasma membrane is rapid, biphasic, temperature dependent, bi-directional, concentration dependent and specific (Massimine et al. 2005).
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Accession Number: | V5B8W0 |
Protein Name: | Folate/biopterin transporter subfamily protein |
Length: | 1057 |
Molecular Weight: | 115066.00 |
Species: | Toxoplasma gondii (strain ATCC 50861 / VEG) [432359] |
Number of TMSs: | 14 |
Substrate |
folic acid, methotrexate, biopterin |
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1: MARMKAVLCA RQWCRRLSPL RLVDFVHSVR RDVGLEFTLM LLSTYVGVKG FLYILATDSL
61: LPFMKDLGYD GLVYQRTVTL AYVPWGMKGL IGLLSDALPV GGYHKRFYML AASLSGVASL
121: VCLLCLARET ARHAAWLIGL LFFCVHVQIA TVDLMCEGMY SQVMVAKPRV GANLVTFVNA
181: CTTVGAFVGR IIVGPVSDRF GARPLFLVAL PVALQSLLPI ALNYLMEERV RPGCTLLTEK
241: LRDHKKVFLM AFAVAAGASG VAVLTLVGGR GTTYILPYCG VVSVLLIVLC AVCLPPQLAK
301: CNVFFFLDRI LHVSISGALD FFYTASPACV PDGPHFDYTY YSTYTAVAGT LATWLGLVLF
361: QLALSSWTYR SIFWLTSAVR ILASLFDYVM TTRLNLRLGI PDKFMYLFGD AIILSVIGTL
421: SHMPGVILTS RLCPPRIEST VYAILAGISN FGHSVSTLLG IRAIKAANIT TTATDGHACN
481: FENLPALVLI AHCVLPMASI PLALFLLPST PMDESLEHFD SDCMRRESEA GAEAGVSSDE
541: ATRDVHRRTV ERRTRGGKVA ETELALMETR GENRTRAREN RTFGACVHHA LSTTDDEDSG
601: GYRDEDEFDA TRKPRIFGRE RIYTDGDVDL GNATTFQVLP VLGDDHEGGD LTDAMGVPVF
661: FPFSRRGQRG GVAASWKKDG EESGGHEESR EKQPQARNAR VRRGATGQRP RTSYSLCASD
721: QLSPTASPRG CFSGQDSELT FAVSSEEDAS EGPNADSVRR ASADEQGVCV VGHHAVAAEH
781: MRRPFSPFSS SSLSFEEEEE RAGRRSGRSA VYEEEDRSED GERRSTFASD SGRVDGEAGE
841: FGDDEVLFAS EDAETTAALP VEHAEENMGK WRRNTEENVS SDSRSTATPP YTKARLPPPS
901: SNLPDRDSPS FLLESETPSA PVSYISTPLS VQSASVSASV SCSSSVRHSP FPSSFTSSSP
961: TDLGWGAAAH HGRREGKSPS GPPLAQAARR ADADPSSLGM HAVFSDTFGP RRTFVEETRP
1021: QLDLDAEEGS QRSTLGDETA STEDKDLYLF HQTEEER