2.A.71.2.2 Folate/biopterin uptake carrier, Fbp. Transports 5-formyl tetrahydrofolate monoglutamate but not 5-formyltetrahydrofolate triglutamate. (Also transports methotrexate and aminopterin) (Klaus et al., 2005) (Nine homologues are present in Arabidopsis thaliana.) (Klaus et al., 2005). Mutational analyses suggest that the folate binding site involves the core helices 1, 4, 7 and 10 and is in the center of the membrane (Eudes et al., 2010).
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Accession Number: | Q9SKZ5 |
Protein Name: | Expressed protein |
Length: | 560 |
Molecular Weight: | 60707.00 |
Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
Number of TMSs: | 12 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
folic acid, methotrexate, biopterin, 4-aminofolic acid |
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RefSeq: |
NP_565734.1
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Entrez Gene ID: |
817764
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Pfam: |
PF03092
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KEGG: |
ath:AT2G32040
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[1] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.” Lin X. et.al. 10617197
[2] “Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.” Reiland S. et.al. 19376835
[3] “Full-length messenger RNA sequences greatly improve genome annotation.” Haas B.J. et.al. 12093376
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1: MASRSLFSIS ISPSQFTVLP SINNERRRLA IAARSHRLSR RKIRKRPPDR DMSSIVSIPE
61: LPRRRDSEES LLLDSRISVA EGDTSNTDVE GDRDTTSSIR TQPPPRKGRN LSSSRIKFYG
121: VELSPDNVAV AMVYFVQGVL GLARLAVSFY LKDDLHLDPA ETAVITGLSS LPWLVKPLYG
181: FISDSVPLFG YRRRSYLVLS GLLGAFSWSL MAGFVDSKYS AAFCILLGSL SVAFSDVVVD
241: SMVVERARGE SQSVSGSLQS LCWGSSAFGG IVSSYFSGSL VESYGVRFVF GVTALLPLIT
301: SAVAVLVNEQ RVVRPASGQK ENITLLSPGF LQTSKQNMIQ LWGAIKQPNV FLPTLFIFLW
361: QATPHSDSAM FYFTTNKLGF TPEFLGRVKL VTSIASLLGV GLYNGFLKTV PLRKIFLVTT
421: IFGTGLGMTQ VILVSGFNRQ LGISDEWFAI GDSLILTVLA QASFMPVLVL AARLCPEGME
481: ATLFATLMSI SNGGSVLGGL MGAGLTQAFG ITRDSFGNLS TLIILCNLSS LLPLPLLGLL
541: PRDSPDTLTK DDADVEMKSN