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2.A.8.1.4 High affinity D-Gluconate:H⁺ symporter, GntT (GntM, UsgA, YhgC) of 438 aas and 11 or 12 TMSs (Porco et al., 1997). It is regulated at the transcriptional level by GntR and Crp (Peekhaus and Conway 1998).
Accession Number:	P39835
Protein Name:	GntT
Length:	438
Molecular Weight:	45967.00
Species:	Escherichia coli [83333]
Number of TMSs:	11
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	D-gluconate

RefSeq:	AP_004375.1 YP_026217.1
Entrez Gene ID:	947924
Pfam:	PF02447
BioCyc:	EcoCyc:GNTT-MONOMER
KEGG:	ecj:JW5690 eco:b3415
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015128 F:gluconate transmembrane transporter activity GO:0019521 P:D-gluconate metabolic process GO:0015725 P:gluconate transport
References (9) [1] “Analysis of the Escherichia coli gntT and gntU genes and comparison of the products with their homologues.” Yamada M.et.al. 8987614 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.” Riley M.et.al. 16397293 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “Molecular characterization of malQ, the structural gene for the Escherichia coli enzyme amylomaltase.” Pugsley A.P.et.al. 2845225 [6] “Intrinsic and extrinsic approaches for detecting genes in a bacterial genome.” Borodovsky M.et.al. 7984428 [7] “Mutations affecting gluconate catabolism in Escherichia coli. Genetic mapping of the locus for the thermosensitive gluconokinase.” Isturiz T.et.al. 3040894 [8] “Molecular genetic characterization of the Escherichia coli gntT gene of GntI, the main system for gluconate metabolism.” Porco A.et.al. 9045817 [9] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MPLVIVAIGV ILLLLLMIRF KMNGFIALVL VALAVGLMQG MPLDKVIGSI KAGVGGTLGS 
61:	LALIMGFGAM LGKMLADCGG AQRIATTLIA KFGKKHIQWA VVLTGFTVGF ALFYEVGFVL 
121:	MLPLVFTIAA SANIPLLYVG VPMAAALSVT HGFLPPHPGP TAIATIFNAD MGKTLLYGTI 
181:	LAIPTVILAG PVYARVLKGI DKPIPEGLYS AKTFSEEEMP SFGVSVWTSL VPVVLMAMRA 
241:	IAEMILPKGH AFLPVAEFLG DPVMATLIAV LIAMFTFGLN RGRSMDQIND TLVSSIKIIA 
301:	MMLLIIGGGG AFKQVLVDSG VDKYIASMMH ETNISPLLMA WSIAAVLRIA LGSATVAAIT 
361:	AGGIAAPLIA TTGVSPELMV IAVGSGSVIF SHVNDPGFWL FKEYFNLTIG ETIKSWSMLE 
421:	TIISVCGLVG CLLLNMVI

2.A.8.1.4
High affinity D-Gluconate:H⁺ symporter, GntT (GntM, UsgA, YhgC) of 438 aas and 11 or 12 TMSs (Porco et al., 1997). It is regulated at the transcriptional level by GntR and Crp (Peekhaus and Conway 1998).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

2.A.8.1.4High affinity D-Gluconate:H+ symporter, GntT (GntM, UsgA, YhgC) of 438 aas and 11 or 12 TMSs (Porco et al., 1997). It is regulated at the transcriptional level by GntR and Crp (Peekhaus and Conway 1998).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

2.A.8.1.4
High affinity D-Gluconate:H⁺ symporter, GntT (GntM, UsgA, YhgC) of 438 aas and 11 or 12 TMSs (Porco et al., 1997). It is regulated at the transcriptional level by GntR and Crp (Peekhaus and Conway 1998).