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2.A.82.1.3
Transmembrane protein 184B (Putative MAPK-activating protein FM08).  It has been concluded that this protein is responsible for ibuprofin and possibly taurine uptake, and that its gene expression is regulated by the Nfat5 transcription factor (Rasmussen et al. 2019).

Accession Number:Q9Y519
Protein Name:Transmembrane protein 184B
Length:407
Molecular Weight:45562.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Entrez Gene ID: 25829    25829   
Pfam: PF03619    PF03619   
KEGG: hsa:25829    hsa:25829   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0016021 C:integral to membrane

References (24)

[1] “Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.”  Matsuda A.et.al.   12761501
[2] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[5] “The DNA sequence of human chromosome 22.”  Dunham I.et.al.   10591208
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[8] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[9] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[10] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[11] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[12] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332
[13] “Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.”  Matsuda A.et.al.   12761501
[14] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[15] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[16] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[17] “The DNA sequence of human chromosome 22.”  Dunham I.et.al.   10591208
[18] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[19] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[20] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[21] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[22] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[23] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[24] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTVRGDVLAP DPASPTTAAA SPSVSVIPEG SPTAMEQPVF LMTTAAQAIS GFFVWTALLI 
61:	TCHQIYMHLR CYSCPNEQRY IVRILFIVPI YAFDSWLSLL FFTNDQYYVY FGTVRDCYEA 
121:	LVIYNFLSLC YEYLGGESSI MSEIRGKPIE SSCMYGTCCL WGKTYSIGFL RFCKQATLQF 
181:	CVVKPLMAVS TVVLQAFGKY RDGDFDVTSG YLYVTIIYNI SVSLALYALF LFYFATRELL 
241:	SPYSPVLKFF MVKSVIFLSF WQGMLLAILE KCGAIPKIHS ARVSVGEGTV AAGYQDFIIC 
301:	VEMFFAALAL RHAFTYKVYA DKRLDAQGRC APMKSISSSL KETMNPHDIV QDAIHNFSPA 
361:	YQQYTQQSTL EPGPTWRGGA HGLSRSHSLS GARDNEKTLL LSSDDEF