TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.89.1.1









The vacuolar Fe2+/Mn2+ uptake transporter, Ccc1
Eukaryota
Fungi
Ccc1 of Saccharomyces cerevisiae (322 aas; P47818)
2.A.89.1.2









The vacuolar Fe2+ uptake transporter, VIT1 of 250 aas and 5 putative TMSs (Gollhofer et al. 2011). The crystal structure of the orthogous VIT1 from rose gum, Eucalyptus grandis, which probably functions as a H+-dependent antiporter for Fe2+ and other transition metal ions, has been solved. VIT1 adopts a novel protein fold forming a dimer of five membrane-spanning domains, with an ion-translocating pathway constituted by the conserved methionine and carboxylate residues at the dimer interface. The second transmembrane helix protrudes from the lipid membrane by about 40 Å, and connects to a three-helical bundle, triangular, cytoplasmic domain, which binds to the substrate metal ions in preparation for their transport (Kato et al. 2019).

Eukaryota
Viridiplantae
VIT1 of Arabidopsis thaliana (Q9ZUA5)
2.A.89.1.3









Uncharacterized protein of 242 aas and 5 TMSs

Bacteria
Bacteroidetes/Chlorobi group
Uncharacterized protein of Marivirga tractuosa
2.A.89.1.4









Uncharacterized protein of 252 aas with 5 TMSs

Bacteria
Chlamydiae/Verrucomicrobia group
Uncharacterized protein of Parachlamydia acanthamoebae
2.A.89.1.5









CCC1 (VIT) family protein of 248 aas

Bacteria
Chlamydiae/Verrucomicrobia group
VIT family protein of Chlamydia trachomatis
2.A.89.1.6









Uncharacterized protein of 173 aas and 5 TMSs.

Bacteria
Candidatus Sungbacteria
UP of Candidatus Sungbacteria bacterium
2.A.89.1.7









VIT family protein of 192 aas and 5 TMSs in a 2 + 3 TMS arrangement

Archaea
Euryarchaeota
VIT protein of Methanobacterium sp.
2.A.89.1.8









Uncharacterized protein of 183 aas and 5 TMSs in a 2 + 3 TMS arrangement.

Archaea
Crenarchaeota
UP of Sulfolobus sp. A20
2.A.89.1.9









Uncharacterized protein of 194 aas and 5 TMSs.

Bacteria
Proteobacteria
UP of Nitrosococcus halophilus
2.A.89.1.10









VIT family protein, partial, of 214 aas and 5 TMSs

Archaea
Candidatus Lokiarchaeota
VIT family protein of Lokiarchaeum sp. GC14_75 (marine sediment metagenome)
2.A.89.1.11









Uncharacterized VIT family protein of 222 aas and 5 TMSs in a 2 + 3 TMS arrangement.

Archaea
Candidatus Thorarchaeota
UP of Candidatus Thorarchaeota archaeon AB_25 (marine sediment metagenome)
2.A.89.1.12









Uncharacterized protein of 203 aas and 5 TMSs in a 2 + 3 TMS arrangement.

Archaea
Candidatus Odinarchaeota
UP of Candidatus Odinarchaeota archaeon LCB_4 (hot springs metagenome)
2.A.89.2.1









Bacteria
Proteobacteria
VIT family member of Rhizobium leguminosarum
2.A.89.2.2









Membrane-bound ferritin-like ferrous iron (Fe2+) exporter, MbfA, of the erythrin-vacuolar iron transport-1 (Er-VIT1) family of 327 aas.  The protein has an N-terminal ferritin domain and a C-terminal VIT domain of 5 established TMSs (Bhubhanil et al. 2014).

Bacteria
Proteobacteria
MbfA of Agrobacterium tumefaciens
2.A.89.2.3









VIT family member of 2690 aas and 5 TMSs.

Bacteria
Proteobacteria
VIT of Bartonella clarridgeiae
2.A.89.3.1









The bacterial VIT family homologue

Bacteria
Proteobacteria
VIT homologue of Burkholderia phytofirmans (376 aas; B2TCH9)
2.A.89.3.2









VIT family member, Spr0814 (Becker et al., 2009).

Bacteria
Firmicutes
Spr0814, VIT family member of Streptococcus pneumoniae (E1H0W3)
2.A.89.3.3









Vacuolar Nodulin-like1 (At1g21140) Iron regulated (Gollhofer et al., 2011).

Eukaryota
Viridiplantae
VIT homolog1 of Arabidopsis thaliana (Q9LPU9)
2.A.89.3.4









Nodulin-like2 (At1g76800) Iron regulated (Gollhofer et al., 2011).

Eukaryota
Viridiplantae
VIT homolog2 of Arabidopsis thaliana (Q9SR03)
2.A.89.3.5









Nodulin-like2.1 (At3g25190) Iron regulated; involved in Fe homeostasis (Gollhofer et al., 2011).

Eukaryota
Viridiplantae
VIT homolog2.1 of Arabidopsis thaliana (Q9LSF6)
2.A.89.3.6









Nodulin-like3 (At3g43630) Not iron regulated; involved in Fe homeostasis (Gollhofer et al., 2011).

Eukaryota
Viridiplantae
VIT3 of Arabidopsis thaliana (Q9M2C3)
2.A.89.3.7









Nodulin-like4 (At3g43660) Not iron regulated (Gollhofer et al., 2011).

Eukaryota
Viridiplantae
VIT4 of Arabidopsis thaliana (Q9M2C0)
2.A.89.3.8









Fe2+/Mn2+ transporter Pcl1 (Pombe ccc1-like protein 1)

Eukaryota
Fungi
Pcl1 of Schizosaccharomyces pombe
2.A.89.3.9









VIT family protein of 413 aas with an N-terminal rubrerythrin-like (ferritin-like) domain and a C-terminal DUF125 (5 TMS) domain.

Bacteria
Chlamydiae/Verrucomicrobia group
VIT family protein of Methylacidiphilum infernorum (Methylokorus infernorum)
2.A.89.3.10









The archaeal VIT family homologue
Archaea
Euryarchaeota
VIT homologue of Pyrococcus abyssi (364 aas; CAB50539)