2.A.90.1.4
STRA6 of 670 aas, mediates cellular
uptake of vitamin A by recognizing RBP-retinol to trigger release and
internalization of retinol. Chen et al. 2016 presented the structure of zebrafish STRA6,
determined to 3.9-angstrom resolution by single-particle cryo-electron
microscopy. STRA6 has one intramembrane and nine transmembrane helices
in an intricate dimeric assembly. Calmodulin is bound
tightly to STRA6 in a noncanonical arrangement. Residues involved with
RBP binding map to an arch-like structure that covers a deep lipophilic
cleft. This cleft is open to the membrane, suggesting a possible mode
for internalization of retinol through direct diffusion into the lipid
bilayer.
|
| Accession Number: | Q1ECX5 |
|---|
| Protein Name: | Zgc:136689 |
|---|
| Length: | 670 |
|---|
| Molecular Weight: | 75411.00 |
|---|
| Species: | Danio rerio (Zebrafish) [7955] |
|---|
| Number of TMSs: | 13 |
|---|
| Substrate |
all-trans-retinol |
|---|
1: MSAETVNNYD YSDWYENAAP TKAPVEVIPP CDPTADEGLF HICIAAISLV VMLVLAILAR
61: RQKLSDNQRG LTGLLSPVNF LDHTQHKGLA VAVYGVLFCK LVGMVLSHHP LPFTKEVANK
121: EFWMILALLY YPALYYPLLA CGTLHNKVGY VLGSLLSWTH FGILVWQKVD CPKTPQIYKY
181: YALFGSLPQI ACLAFLSFQY PLLLFKGLQN TETANASEDL SSSYYRDYVK KILKKKKPTK
241: ISSSTSKPKL FDRLRDAVKS YIYTPEDVFR FPLKLAISVV VAFIALYQMA LLLISGVLPT
301: LHIVRRGVDE NIAFLLAGFN IILSNDRQEV VRIVVYYLWC VEICYVSAVT LSCLVNLLML
361: MRSMVLHRSN LKGLYRGDSL NVFNCHRSIR PSRPALVCWM GFTSYQAAFL CLGMAIQTLV
421: FFICILFAVF LIIIPILWGT NLMLFHIIGN LWPFWLTLVL AALIQHVASR FLFIRKDGGT
481: RDLNNRGSLF LLSYILFLVN VMIGVVLGIW RVVITALFNI VHLGRLDISL LNRNVEAFDP
541: GYRCYSHYLK IEVSQSHPVM KAFCGLLLQS SGQDGLSAQR IRDAEEGIQL VQQEKKQNKV
601: SNAKRARAHW QLLYTLVNNP SLVGSRKHFQ CQSSESFING ALSRTSKEGS KKDGSVKEPS
661: KEAESAAASN