2.A.90.2.5
Stimulated by retinoic acid gene 6 protein-like, Str61, RBPR2, of 621 aas and 11 or 12 TMSs. It acts as a high-affinity cell-surface receptor for retinol-binding
protein RBP4 and mediates RBP4-dependent retinol uptake in the liver (Alapatt et al. 2013). The extracellular RBP4 ligand binding domain on the RBPR2 receptor for Vitamin A transporthas been mapped (Radhakrishnan et al. 2023).
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| Accession Number: | Q9DBN1 |
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| Protein Name: | Stimulated by retinoic acid gene 6 protein-like |
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| Length: | 621 |
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| Molecular Weight: | 71003.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
all-trans-retinal, all-trans-retinol |
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1: MLAASTRTRQ INITCDNPVD REVFLHYSLI PSLCIILVLS FLQRREHRRQ RDDTSYLLGN
61: HFGIIVPLDF VGTFSNRWSY GAAFGATANK VMFLFSEGYQ PLTVPQWAQA FVLFIGGMEV
121: GLSYFPFFAC LSSEFQLVSS ILGFSYSLTW FVVTVLQISQ CPHGQFLGRF ETLVFYWPSL
181: LCLGFLLGRF LHMFLKALPV HLGLEPQTEE KSMLEAHQAK HVKQLLSKPR PQEGEKSWFQ
241: TRVYEWDPCF QFPSRMVGTL LLAFICLYLF IVIEFCVFLH VRDKLDMFED KLESYLTHMN
301: ETGTLTPIIL QVKELISVTK GVWVVTILPA ALTCVTYLFH ILACYRKHMK RLWAGDKHFL
361: PQKFHSPSSA ASVVAIARYS GWQIAYILWG YLIIHVVQSL CGVMLMYGLV LPIIHHRGLE
421: MLQGFGLGVL TLSIVVGLII LQVWIAGTFF LQPKLGTSDK QKPLALNNRR AFHNFNYFLF
481: FYNVLLGLGA CLSRLLISCL LGTWLIARID RTIMQSGYEG ADMGFGAWIG MLFVDHYHTN
541: PVLVSFCHIL ITSHKDRKLQ KTVKYWCLNQ SAGPRFSARA RTRWFLLQTL INNPRLVMLR
601: KSKSGHSSGE FTQILLTCSD C