2.A.97.1.6
Mitochondrial LETM2 or SLC55A2 of 491 aas and probably 2 TMSs at approximately residues 130 and 180 (Gyimesi and Hediger 2022). Pancreatic ductal adenocarcinoma (PDAC), primarily originates from the exocrine cells of the pancreas. SLC transporters, [more
than 450 proteins divided into 65 families] is integral to various
cellular processes and represents a promising target in precision
oncology (Cho et al. 2025). SLC55A2 is one of these as it is present in increased amounts in PDAC (Cho et al. 2025).
|
| Accession Number: | Q2VYF4 |
|---|
| Protein Name: | LETM1 domain-containing protein LETM2, mitochondrial |
|---|
| Length: | 491 |
|---|
| Molecular Weight: | 55921.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Mitochondrion inner membrane1 / Single-pass membrane protein2 |
|---|
| Substrate |
hydron, pyruvate |
|---|
1: MAFYSYNSVL AIARTRFPSH FVHPTCSSYS PSCAFLHLPD SHLNKTCMKN YESKKYSDPS
61: QPGNTVLHPG TRLIQKLHTS TCWLQEVPGK PQLEQATKHP QVTSPQATKE TGMEIKEGKQ
121: SYRQKIMDEL KYYYNGFYLL WIDAKVAARM VWRLLHGQVL TRRERRRLLR TCVDFFRLVP
181: FMVFLIVPFM EFLLPVFLKL FPEMLPSTFE SESKKEEKQK KKMAVKLELA KFLQETMTEM
241: ARRNRAKMGD ASTQLSSYVK QVQTGHKPST KEIVRFSKLF EDQLALEHLD RPQLVALCKL
301: LELQTFGTNN LLRFQLLMKL KSIKADDEII AKEGVTALSV SELQAACRAR GMRSLGLTEE
361: QLRQQLTEWQ DLHLKENVPP SLLLLSRTFY LIDVKPKPIE IPLSGEAPKT DILVELPTFT
421: ESKENMVDLA PQLKGTKDED FIQPPPVTSS PITPSTPISL PKGPITSSEE PTLQAKSQMT
481: AQNSKASSKG A