2.A.97.1.7
LetM1 domain-containing protein, LetD1, LTMD1, SLC55A3, of 360 aas and 2 central TMSs (at residues 90 and 140) as well as two possible TMSs at the N- and C-termini of the protein. It is involved in tumorigenesis and may function as a negative regulator of the p53/TP53 pathway (Ko et al. 2003). It may play an essential role for mitochondrial structure and function, and thermogenesis of brown adipocytes. It may also regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (Lim et al. 2020).
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| Accession Number: | Q6P1Q0 |
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| Protein Name: | LETM1 domain-containing protein 1 |
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| Length: | 360 |
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| Molecular Weight: | 41790.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion outer membrane1 / Single-pass membrane protein2 |
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| Substrate |
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1: MALSRVCWAR SAVWGSAVTP GHFVTRRLQL GRSGLAWGAP RSSKLHLSPK ADVKNLMSYV
61: VTKTKAINGK YHRFLGRHFP RFYVLYTIFM KGLQMLWADA KKARRIKTNM WKHNIKFHQL
121: PYREMEHLRQ FRQDVTKCLF LGIISIPPFA NYLVFLLMYL FPRQLLIRHF WTPKQQTDFL
181: DIYHAFRKQS HPEIISYLEK VIPLISDAGL RWRLTDLCTK IQRGTHPAIH DILALRECFS
241: NHPLGMNQLQ ALHVKALSRA MLLTSYLPPP LLRHRLKTHT TVIHQLDKAL AKLGIGQLTA
301: QEVKSACYLR GLNSTHIGED RCRTWLGEWL QISCSLKEAE LSLLLHNVVL LSTNYLGTRR